37103-99-4

Usage

Structure

A heterocyclic organic compound containing a benzene ring fused to an oxazole ring and a dioxolane ring

Applications

Organic synthesis and pharmaceuticals, potential as a building block in the synthesis of biologically active compounds, potential pharmacological activity, and in the development of new drugs and materials.

Upstream product

• 19073-15-5 2-(4-nitrophenyl)-2-methyl-1,3-dioxolane 
• 140-29-4 phenylacetonitrile 

Relevant academic research and scientific papers

Mechanism of formation of 2,1-benzisoxazoles in reactions of nitroarenes with arylacetonitriles

Main regularities in reactions of arylacetonitriles with nitroarenes were discussed. The reaction mechanism has been suggested proceeding from the experimental data and the quantum chemical modeling of the limiting stage, the formation of the 2,1-benzisoxazole ring.

Nucleophilic substitution of hydrogen in activated nitroarenes by phenylacetonitrile carbanion

General relations holding in nucleophilic substitution of hydrogen in para-substituted nitroarenes by phenylacetonitrile carbanion were analyzed in terms of the Klopman reactivity indices. Requirements to the substrate structure were determined, which restrict the scope of application of this method to synthesis of 2,1-benzisoxazole derivatives.