37107-50-9

Usage

Uses

Used in Pharmaceutical Synthesis:
CYCLOHEXYLIDENECYANOACETIC ACID is used as a precursor for the synthesis of various pharmaceuticals and biologically active compounds, leveraging its unique structural features to contribute to the development of new medications.
Used in Organic Chemical Reactions:
CCA is used as a reagent in organic chemical reactions, particularly for the preparation of heterocyclic compounds, where its cyclohexylidene ring and cyano group play crucial roles in the formation of complex molecular structures.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, CYCLOHEXYLIDENECYANOACETIC ACID is utilized for its potential in creating compounds with therapeutic properties, contributing to the advancement of drug discovery and development.
Used in Agrochemicals:
CCA is employed in the agrochemical industry, where its reactivity and structural features can be harnessed to develop new compounds for agricultural applications, such as pesticides or herbicides.
Used in Material Science:
In material science, CYCLOHEXYLIDENECYANOACETIC ACID is used to explore its potential in creating novel materials with unique properties, such as improved strength, flexibility, or chemical resistance.

InChI:InChI=1/C9H11NO2/c10-6-8(9(11)12)7-4-2-1-3-5-7/h1-5H2,(H,11,12)

Upstream product

• 108-94-1 cyclohexanone 
• 105-56-6 ethyl 2-cyanoacetate 
• 4354-73-8 2-(cyclohexylidene)malononitrile 
• 1352994-38-7 3-amino-2-oxa-1-azaspiro[4.5]dec-3-ene-4-carbonitrile 
• 372-09-8 cyanoacetic acid 

Downstream Products

• 6802-76-2 ethyl 2-cyano-2-cyclohexylideneacetate 
• 6975-71-9 1-cyclohexenylacetonitrile 
• 76734-94-6 C₁₂H₁₉NO₂Si 
• 113001-98-2 2-cyanocyclohexylideneacetyl chloride 
• 108-94-1 cyclohexanone 
• 113001-99-3 2-cyanocyclohexylideneacetyl isothiocyanate 
• 113002-01-0 N-(4-methylphenyl)-N'-2-cyanocyclohexylideneacetylthiourea 
• 113002-03-2 1-phenyl-5-cyano-4-oxo-2-thioxo-1,3-diazaspiro<5,5>undecane 
• 113002-04-3 1-(4-methylphenyl)-5-cyano-4-oxo-2-thioxo-1,3-diazaspiro<5,5>undecane 
• 113002-09-8 5-cyano-2-methylphenylamino-4-oxo-1-thia-3-azaspiro<5,5>undec-2-ene 
• 113002-02-1 N-(4-methoxyphenyl)-N'-2-cyanocyclohexylideneacetylthiourea 
• 113002-06-5 1-(4-hydroxyphenyl)-5-cyano-4-oxo-2-thioxo-1,3-diazaspiro<5,5>undecane 
• 113002-08-7 1-(4-bromophenyl)-5-cyano-4-oxo-2-thioxo-1,3-diazaspiro<5,5>undecane 
• 113002-07-6 1-(4-methoxyphenyl)-5-cyano-4-oxo-2-thioxo-1,3-diazaspiro<5,5>undecane 

Relevant academic research and scientific papers

Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles

α,α-Dicyanoolefins react with hydroxylamine to afford 2,3-dihydroisoxazoles (2,3-dihydroisoxazoles can be easily isolated by filtration) in excellent yields under mild and environmentally benign conditions. A one-pot reaction in tandem with an unexpected ring-opening of 2,3-dihydroisoxazoles has been developed as well.

Method for making bicycle lactones from beta, gamma unsaturated cyclic nitriles

A method for making a bicyclic lactone comprising heating under aqueous acidic conditions a beta, gamma unsaturated cyclic nitrile and an aldehyde, for a length of time sufficient to convert at least a portion of the reactants to a bicyclic lactone of the formula STR1 wherein R3 is --H; R4, R5, and R6 are independently selected from the group consisting of --H, --CH3 ; R2 is selected from the group consisting of --H, --CH3, and --CH3, and --C2 H5 ; R8 is --H or --CH3 ; m is an integer from 1 to 5; o is 0, 1, 2, or 3; and p is 0, 1, or 2; provided that the sum of m+o+p is an integer from 3 to 5; either R3 or R8 together with R7 represents a carbon-carbon bond. The method uses commercially available and relatively inexpensive raw materials as reactants.

CINETIQUE ET MECANISME DE LA REACTION DE KNOEVENAGEL DANS LE BENZENE-2 REACTION DU MALONITRILE ET DE LA (+) METHYL-3 CYCLOHEXANONE EN PRESENCE D'UNE AMINE PRIMARIE PURE ET DE SON MELANGE AVEC L'ACIDE ACETIQUE

The kinetics of the reaction of (+)-3-methyl cyclohexanone with malonitrile were studied in benzene at 25 deg C, in the presence of hexylamine-acetic acid mixtures.Hexylamine gives an imine with cyclohexanone in an acid-catalyzed step.This imine then reacts quickly with malononitrile.A rate law of zero order in malononitrile is observed.Separate kinetic results obtained for the formation of the imine and for the imine-malonitrile reaction support this mechanism.Without acetic acid, a complex rate law is observed; hexylamine acts mainly as a basic catalyst.Primary amine-carboxylic acid was used as a catalyst in Knoevenagel reaction, often giving an increase in yield and a diminution in the reaction time compared with the more commonly used catalysts: piperidine, β-alanine, AcOH-AcONH4.

LONG-ACTING CONTRACEPTIVE AGENTS: LEVONORGESTREL ESTERS OF UNSATURATED ACIDS

Esters of levonorgestrel (13β-ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one) with a variety of unsaturated carboxylic acids have been synthesized for evaluation as potential long-acting, injectable contraceptive agents.