371149-39-2

Upstream product

• 371149-32-5 4-methoxyphenyl-4-(2'-thienyl)-4-oxobutanamide 
• 104-94-9 4-methoxy-aniline 
• 59086-25-8 ethyl 4-oxo-4-(thiophen-2-yl)butanoate 

Relevant academic research and scientific papers

Arylamino-thieno-oxobutanainides under Lawesson's conditions: Competition between thienylpyrrole and bithiophene formation

1-Aryl-2-thienyl-substituted pyrroles and/or 5-arylamino-2,2′- bithiophenes were synthesized by treatment of arylamino-thieno-oxobutanamides with Lawesson's reagent. These in turn were prepared by direct amidation of 4-oxo-(2-thienyl)butanoic acid through DCC-BtOH mediated reactions.

A combination of Friedel-Crafts and Lawesson reactions to 5-substituted 2,2′-bithiophenes

γ-Keto esters (2) derivatives of thiophene were obtained from hemisuccinic esters and transformed to the corresponding amides (4). Lawesson's treatment of 2 and 4 gave the corresponding bithiophenes (5) with alkoxy or amino substituents.