371231-91-3Relevant academic research and scientific papers
A new synthesis of 4-cyano-1,3-dihydro-2-oxe-2h-5-(N1-tosyl)carboxamide: Reactive precursor for thiopurine analogues
Hamad,Derbala
, p. 939 - 944 (2001)
N-[(5-Cyano-2-oxoimidazolidin-4-yl)-iminomethyl]-p-toluensulfonamide 3 was prepared in fairly good yield by the base catalyzed cyclisation of N-[(Z)-2-amino-1,2-dicycanovinylcarbamoyl]-p-toluenesulfonamide 2. The N-[(Z)-2-amino-1,2-dicycanovinyl carbamoyl]-p-toluenesulfonamide 2 was reacted readily with two molar amount of p-nitrobenzaldehyde at room temperature in the presence of base to give 7,8-dihydro-2-(4-nitrophenyl)-8-oxo-9-tosylpurine-6-carboxamide 8. Thiation of compounds 3 and 8 using Lawesson's reagent in tetrahydrofuran gave novel thioimidazoles 4, 5, and 6 and thiopurines 9, 10, and 11, which have been characterized spectroscopically.
