37136-86-0

Upstream product

• 3328-57-2 sodium 4-cyanophenolate 
• 109-64-8 1,3-dibromo-propane 
• 767-00-0 4-cyanophenol 

Downstream Products

• 112887-51-1 N-{4-[3-(4-Cyano-phenoxy)-propyl]-morpholin-2-ylmethyl}-acetamide 
• 63360-05-4 4-[3-(4-Acetyl-3-hydroxy-phenoxy)-propoxy]-benzonitrile 
• 141815-37-4 4-[3-(2-Aminomethyl-morpholin-4-yl)-propoxy]-benzonitrile 
• 112886-67-6 4-Amino-5-chloro-N-{4-[3-(4-cyano-phenoxy)-propyl]-morpholin-2-ylmethyl}-2-methoxy-benzamide 
• 141814-55-3 4-Amino-5-chloro-N-{4-[3-(4-cyano-phenoxy)-propyl]-morpholin-2-ylmethyl}-2-ethoxy-benzamide 
• 91945-13-0 5-[4-(4-Cyanophenoxy)butyl]-3-methylisoxazole 
• 854895-25-3 2-(3-(3-(4-cyanophenoxy)propoxy)phenyl)benzofuran-5-carbonitrile 
• 854895-33-3 2-(3-(3-(4-cyanophenoxy)propoxy)phenyl)benzofuran-6-carbonitrile 
• 854895-37-7 2-(4-(3-(4-cyanophenoxy)propoxy)phenyl)benzofuran-6-carbonitrile 
• 854895-29-7 2-(4-(3-(4-cyanophenoxy)propoxy)phenyl)benzofuran-5-carbonitrile 
• 1208149-51-2 4''-(3'-(7,9-diamino-6,8,10-triazaspiro[4.5]deca-7,9-dien-6-yloxy)propyloxy)benzonitrile hydrochloride 
• 1208149-69-2 4''-(3'-(2,4-diamino-1,3,5-triazaspiro[5.5]undeca-2,4-dien-1-yloxy)propyloxy)benzonitrile hydrochloride 
• 17954-81-3 4-(3-bromopropoxy)benzaldehyde 

Relevant academic research and scientific papers

The synthesis and biological evaluation of nucleobases/tetrazole hybrid compounds: A new class of phosphodiesterase type 3 (PDE3) inhibitors

Spired by the chemical structure of Cilostazol, a selective phosphodiesterase 3A (PDE3A) inhibitor, several novel hybrid compounds of nucleobases (uracil, 6-azauracil, 2-thiuracil, adenine, guanine, theophylline and theobromine) and tetrazole were designe

AMIDINE SUBSTITUTED ANALOGUES AND USES THEREOF

The present application relates to amidine substituted analogues as shown in formula I and uses thereof as an anti-inflammatory agent and/or for the treatment of an immunological disorder or of an inflammatory bowel disease including ulcerative colitis, C

Synthesis of new compounds with promising antiviral properties against group A and B Human Rhinoviruses

The human common cold, which is a benign disease caused by the Rhinoviruses, generally receives palliative symptomatic treatments, since no specific therapy against any of these viruses currently exists. In this work, some original synthetic compounds wer

Antifolate and antiproliferative activity of 6,8,10-triazaspiro[4.5]deca-6,8-dienes and 1,3,5-triazaspiro[5.5]undeca-1,3-dienes

Two series of triazaspiroalkanedienes, bearing a substituted phenoxy propyloxy side chain, were identified as potent mammalian DHFR inhibitors. One series has a 6,5-spiro bicyclic ring system and the other series has a 6,6-spiro bicyclic system. Both seri

Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif

Forty-eight cationically substituted pentamidine congeners possessing benzofuran rings were synthesized by a copper mediated heteroannulation of substituted o-iodophenols with phenyl acetylenes. Activities of compounds 1-48 against Trypanosoma brucei rhod

Muscarinic acetylcholine receptor antagonists

Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.

Bispidine compounds useful in the treatment of cardiac arrythmias

There is provided compounds of formula I, 1 wherein R1, R2, R3, R4, R5, R6, R7, R41, R42, R43 R44, R45, R46, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

Synthesis and pharmacological evaluation of N-acyl-1,2,3,4- tetrahydroisoquinoline derivatives as novel specific bradycardic agents

A series of N-acyl-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized and evaluated for their bradycardic activities in isolated guinea pig right atria and in urethane-anesthetized rats. These efforts resulted in identification of the compound 8a

Octahydro-2H-pyrido[1,2-a] pyrazine compounds

A compound selected from those of formula (I): 1wherein: Ra represents linear or branched (C1-C6)alkylene, X represents a group selected from W1, —C(W1)—W2—, —W2—C(W1)—, —W2—C(W1)W2—, —W2-Ra- and —CH(OR1)— wherein W1, W2 and R1 are as defined in the description, when Y represents aryl or heteroaryl, or X represents a group selected from single bond, —C(W1)—, —W2—C(W1)—, —W2-Ra and —CH(OR1)— wherein W1, W2, Ra and R1 are as defined hereinbefore, when Y represents a fused bicyclic group, of formula: 2?wherein: A represents nitrogen-containing heterocycle having from 4 to 7 ring members that is unsaturated or partially saturated and optionally contains a second hetero atom, B represents phenyl ring optionally substituted by one or more groups as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, medicinal products containing the same are useful in the treatment of cognitive deficiencies.

Oxabispidine compounds useful in the treatment of cardiac arrhyythmias

There is provided compounds of formula I, wherein R1, R2, R3, R4, R41to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.