3714-60-1 Usage
Enzyme inhibitor
This ATP and dATP analogue (FWfree-acid = 507.18 g/mol; CAS 3714-60-1), also known as 9-(5-O-(hydroxy(hydroxy(phosphonooxy) phosphinyl)phosphinyl)-b-D-arabinofuranosyl)-9H-purin-6-amine,Ara-ATP, adenine arabinoside 5’-triphosphate, and vidarabine 5’-triphosphate, is incorporated into viral DNA, thus inhibiting viral polymerase-mediated DNA synthesis via chain termination. Note: Some DNA polymerases are known to extend chains ending in the ara-nucleotide. Ara-ATP is available commercially for in vitro experimentation. Target(s): DNA primase; mRNA translocation; DNA-directed DNA polymerase; DNA polymerase a; DNA polymerase b; DNA polymerase g; ribonucleotide reductase; S-adenosylhomocysteine hydrolase; RNA polymerase; polynucleotide adenylyltransferase; GMP synthetase; lysyltRNA synthetase; leucyl-tRNA synthetase; adenylate cyclase; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, possible alternative substrate; duck hepatitis B virus reverse transcriptase; RNA-directed DNA polymerase; DNA nucleotidyl exotransferase, or terminal deoxyribonucleotidyl transferase.
Check Digit Verification of cas no
The CAS Registry Mumber 3714-60-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,1 and 4 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3714-60:
(6*3)+(5*7)+(4*1)+(3*4)+(2*6)+(1*0)=81
81 % 10 = 1
So 3714-60-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7+,10-/m1/s1
3714-60-1Relevant academic research and scientific papers
Derivatives of L-adenosine and L-guanosine as substrates for human deoxycytidine kinase
Gaubert,Gosselin,Imbach,Eriksson,Maury
, p. 857 - 860 (2007/10/03)
A series of analogues of L-adenosine and of L-guanosine, including β- L-dA, β-L-Ado, β-L-araA, and β-L-dG, have been shown to be substrates of human deoxycytidine kinase thus demonstrating the complete lack of enantioselectivity of this enzyme.
