37148-86-0

Basic information

• Product Name: 4-(4-TRIFLUOROMETHYL-PHENYL)-1H-IMIDAZOLE
• Synonyms: 4-(4-TRIFLUOROMETHYL-PHENYL)-1H-IMIDAZOLE
• CAS NO: 37148-86-0
• Molecular Formula: C₁₀H₇F₃N₂
• Molecular Weight: 212.1711896
• Mol File: 37148-86-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(4-TRIFLUOROMETHYL-PHENYL)-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-TRIFLUOROMETHYL-PHENYL)-1H-IMIDAZOLE(37148-86-0)
• EPA Substance Registry System: 4-(4-TRIFLUOROMETHYL-PHENYL)-1H-IMIDAZOLE(37148-86-0)

Safety Data

• Hazardous Substances Data: 37148-86-0(Hazardous Substances Data)

Usage

General Description

4-(4-trifluoromethyl-phenyl)-1H-imidazole is a chemical compound with the molecular formula C10H7F3N2. It is commonly used as a pharmaceutical intermediate and in the synthesis of various medicinal compounds. The trifluoromethyl group on the phenyl ring makes this compound highly electron-withdrawing and contributes to its potential as a building block for drug discovery. 4-(4-trifluoromethyl-phenyl)-1H-imidazole has properties that make it suitable for use in various applications, including the treatment of diseases and disorders in the pharmaceutical industry, and it is also used as a research tool in chemical and biological research.

Upstream product

• 186581-53-3 diazomethane 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 
• 77287-34-4 formamide 

Downstream Products

• 1181214-82-3 4-[1-(4-heptafluoropropyloxyphenyl)-1H-[1,2,4]triazol-3-yl]-phenylamine 
• 1181214-24-3 4-[4-(4-trifluoromethylphenyl)-1H-imidazol-1-yl]-benzonitrile 
• 774522-73-5 3-[5-(4-trifluoromethyl-phenyl)-imidazol-1-ylmethyl]-benzoic acid 
• 218131-42-1 3-[5-(4-trifluoromethyl-phenyl)-imidazol-1-ylmethyl]-benzoic acid methyl ester 
• 218131-40-9 3-[4-(4-trifluoromethyl-phenyl)-imidazol-1-yl]-propionitrile 

Relevant articles and documents

One-pot synthesis of 2-alkyl-4(5)-aryl-1H-imidazoles from 1-aryl-2-bromoethanones, ammonium carbonate and aliphatic carboxylic acids

A simple and efficient protocol for the preparation of 2-alkyl-4(5)-aryl- 1H-imidazoles starting from α-bromo aryl methyl ketones and aliphatic carboxylic acids in the presence of ammonium carbonate has been developed.

Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists

An imidazolylpyrimidine was identified in a CXCR2 chemokine receptor antagonist screen and was optimized for potency, in vitro metabolic stability, and oral bioavailability. It was found that subtle structural modification within the series affected the o

SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) BENZOHETEROARYL COMPOUNDS

This invention is directed to an (aminoiminomethyl or aminomethyl) benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.