3717-15-5

Basic information

• Product Name: (αE)-N-Hydroxy-4-methylbenzenemethaneimine
• Synonyms: (E)-4-Methylbenzaldehyde oxime;(E)-p-Tolualdehyde oxime;(αE)-N-Hydroxy-4-methylbenzenemethaneimine;syn-p-Tolualdoxime;(NE)-N-[(4-methylphenyl)methylidene]hydroxylamine
• CAS NO: 3717-15-5
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.1632
• Mol File: 3717-15-5.mol
• Article Data: 150

Chemical Properties

• Melting Point: 78 °C
• Boiling Point: 216.8°Cat760mmHg
• Flash Point: 116.4°C
• Appearance: /
• Density: 1.01g/cm³
• Vapor Pressure: 0.0804mmHg at 25°C
• Refractive Index: 1.518
• PKA: 10.83±0.10(Predicted)
• CAS DataBase Reference: (αE)-N-Hydroxy-4-methylbenzenemethaneimine(CAS DataBase Reference)
• NIST Chemistry Reference: (αE)-N-Hydroxy-4-methylbenzenemethaneimine(3717-15-5)
• EPA Substance Registry System: (αE)-N-Hydroxy-4-methylbenzenemethaneimine(3717-15-5)

Safety Data

• Hazardous Substances Data: 3717-15-5(Hazardous Substances Data)

Usage

General Description

(αE)-N-Hydroxy-4-methylbenzenemethaneimine, also known as 4-methylbenzylhydroxylamine, is an organic compound with the chemical formula C8H11NO. It is an important intermediate in the production of pharmaceuticals and agrochemicals, as well as a potential precursor for the synthesis of various other organic compounds. This chemical is also known for its ability to act as a chelating agent, which means it can bind to metal ions and form stable complexes. Its unique structure and properties make it a valuable compound in organic synthesis and chemical research. Additionally, it is also used in the manufacturing of various rubber and plastic products, as well as in the synthesis of antioxidants and corrosion inhibitors.

InChI:InChI=1/C8H9NO/c1-7-2-4-8(5-3-7)6-9-10/h2-6,10H,1H3/b9-6-

Upstream product

• 2403-51-2 2-(4-methylphenyl)-1,3-dioxolane 
• 75-52-5 nitromethane 
• 108-88-3 toluene 
• 22755-24-4 sodium salt of nitromethane 
• 104-87-0 4-methyl-benzaldehyde 
• 589-18-4 4-Methylbenzyl alcohol 
• 98180-43-9 bis(4-methylbenzyl)amine 
• 87-91-2 diethyl (2R,3R)-tartrate 
• 3717-16-6 (Z)-4-methylbenzaldehyde oxime 
• 2168-80-1 4-methyldithioic acid 
• 92114-96-0 mercury fulminate 
• 106-49-0 p-toluidine 
• 110-89-4 piperidine 
• 119991-08-1 4-Methyl-benzaldehyde O-(2,4-dinitro-phenyl)-oxime 

Downstream Products

• 3717-16-6 (Z)-4-methylbenzaldehyde oxime 
• 26218-73-5 3,4-bis(4-methylphenyl)-1,2,5-oxadiazole-N-oxide 
• 36288-37-6 N-hydroxy-4-methylbenzenecarboximidoyl chloride 
• 112350-95-5 Monoethyl--orthopropionat 
• 102740-26-1 4-(4-methylphenyl)-2,7-dioxa-3-azabicyclo<3,3,0>oct-3-ene 
• 135921-73-2 (3aR,8bR)-3-p-Tolyl-3a,8b-dihydro-benzo[4,5]thieno[2,3-d]isoxazole 4,4-dioxide 
• 135921-77-6 (3aS,8bR)-3a-Chloro-3-p-tolyl-3a,8b-dihydro-benzo[4,5]thieno[2,3-d]isoxazole 4,4-dioxide 
• 7050-78-4 4-Methyl-O-<2,4-dimethyl-phenoxycarbimidoyl>benzaldoxim 
• 65786-02-9 C₁₅H₁₃N₃O₄ 
• 104-85-8 para-methylbenzonitrile 
• 99-94-5 p-Toluic acid 
• 81386-30-3 5-methyl-3-(4-methylphenyl)-1,2,4-oxadiazole 
• 243980-62-3 (5R,7S,8R,9R,10S)-8,9,10-Tris(benzyloxy)-7-methoxy-3-(4-methylphenyl)-1,6-dioxa-2-azaspiro[4.5]dec-2-ene 
• 26166-61-0 1-(dinitromethyl)-4-methylbenzene 

Relevant articles and documents

A catalytic regioselective procedure for the synthesis of aryl oximes in the presence of palladium nanoparticles

The synthesis of aryl oximes from aryl aldehyde derivatives was carried out using hydroxylamine hydrochloride and aluminum oxy hydroxide-supported palladium (Pd/AlO(OH) nanoparticles. The procedure is revealed via the regioselective synthesis of oxime der

Poly(N-vinylimidazole): A biocompatible and biodegradable functional polymer, metal-free, and highly recyclable heterogeneous catalyst for the mechanochemical synthesis of oximes

The catalytic activity of poly(N-vinylimidazole), a biocompatible and biodegradable synthetic functional polymer, was investigated for the synthesis of oximes as an efficient, halogen-free, and reusable heterogeneous catalyst. The corresponding oximes were afforded in high to excellent yields at room temperature and in short times using the planetary ball mill technique. Some merits, such as the short reaction times and good yields for poorly active carbonyl compounds, and avoiding toxic, expensive, metal-containing catalysts, and hazardous and flammable solvents, can be mentioned for the current catalytic synthesis of the oximes. Furthermore, the heterogeneous organocatalyst could be easily separated after the reaction, and the regenerated catalyst was reused several times with no significant loss of its catalytic activity.

1,3-dipolar cycloaddition reactions of the compound obtaining from cyclopentadiene-PTAD and biological activities of adducts formed selectively

After known adduct (4) was synthesized by cycloaddition reaction of cyclopentadiene with 4-phenyl-1,2,4-triazoline-3,5-dione, seven new isoxazoline derivatives were synthesized from reactions of 4 with corresponding oximes prepared from benzaldehyde derivatives in the existence of the aqueous NaOCl in CH2Cl2 at 0°C—RT via nitrile oxides. Four new pyrazoline derivatives were also synthesized from reactions of 4 with corresponding prepared reagents via nitrile imines. Selectively, each of all isoxazole and pyrazoline derivatives was synthesized by 1,3-dipolar cycloaddition reactions of compound 4 with the corresponding reagents. Based on the results of their biological activity analyses, Ki values for acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glucosidase (α-Gly) enzymes were obtained in this range 32.15 ± 5.73–107.44 ± 19.52 22.57 ± 4.30–186.07 ± 23.51, and 69.08 ± 8.54–528.07 ± 38.46 nM, respectively. Besides that, these compounds were subjected to molecular docking to describe the interaction against AChE, BChE, and α-Gly enzymes in which important interactions were visualized and evaluated with residues of the binding region in each target enzyme.