3717-26-8

Basic information

• Product Name: 2-CHLOROBENZALOXIME
• Synonyms: 2-CHLOROBENZALOXIME;2-Chlor-benzaldehyd-(E)-oxim;2-chloro-benzaldehyde (E)-oxime;2-CHLOROBENZALDOXIME;E-2-chlorobenzaldoxime
• CAS NO: 3717-26-8
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.58164
• Mol File: 3717-26-8.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLOROBENZALOXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROBENZALOXIME(3717-26-8)
• EPA Substance Registry System: 2-CHLOROBENZALOXIME(3717-26-8)

Safety Data

• Hazardous Substances Data: 3717-26-8(Hazardous Substances Data)

Upstream product

• 24393-43-9 (E)-ethyl 3-(2-chlorophenyl)-2-cyanoacrylate 
• 96-29-7 ethyl methyl ketone oxime 
• 89-98-5 2-chloro-benzaldehyde 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 2698-41-1 o-chlorobenzylidene malononitrile 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 590-28-3 potassium cyanate 
• 880141-55-9 2-chloro-benzaldehyde-(O-ethoxycarbonyl-seqtrans-oxime ) 
• 7647-01-0 hydrogenchloride 
• 3717-26-8 (E)-2-chlorobenzaldehyde oxime 
• 71-43-2 benzene 

Downstream Products

• 29568-74-9 2-chloro-N-hydroxybenzimidoyl chloride 
• 873-32-5 2-Chlorobenzonitrile 
• 3717-26-8 2-chlorobenzaldoxime 
• 63564-19-2 [1-(2-Chloro-phenyl)-meth-(E)-ylideneaminooxy]-acetic acid 
• 55606-45-6 N-(2-chlorobenzyl)hydroxylamine 
• 138447-14-0 3-(2-Chlorophenyl)-5-benzyl-5-(1,2,4-triazol-1-ylmethyl)-isoxazoline 
• 86339-13-1 N-benzoyloxy-2-chloro-benzamidine 
• 168481-89-8 3,4-bis(2-chlorophenyl)-1,2,5-oxadiazole 2-oxide 
• 56935-60-5 2-chloro-benzamide oxime 
• 261704-60-3 3-(2-chlorophenyl)-5-(phenyl)-1,2,4-oxadiazole 
• 141891-30-7 2-[1-(2-Chloro-phenyl)-meth-(E)-ylideneaminooxy]-butyric acid 
• 141891-28-3 2-[1-(2-Chloro-phenyl)-meth-(E)-ylideneaminooxy]-propionic acid 

Relevant articles and documents

Water mediated procedure for preparation of stereoselective oximes as inhibitors of MRCK kinase

Stereoselective aldoximes, preferably Z form have been obtained from α-cyano substituted carbonyl conjugated alkenes. This reaction occurs through Michael addition type reaction followed by retro-Knoevenagel reaction without transition-metal catalysis via C–C bond cleavage. These oximes are evaluated against cancer cell lines employing mechanistic study. Two oximes showed significant cytotoxic activity, which through in silico studies were found to inhibit MRCK Kinase, responsible for metastatic spread of cancer mortality.

Br?nsted acid catalyzed transoximation reaction: Synthesis of aldoximes and ketoximes without use of hydroxylamine salts

The transoximation reaction enables the transfer of an oxime to a carbonyl compound and is catalyzed by transoximase in the pupae of the silkworm. Inspired by this bio-synthetic pathway, we achieved the transoximation of oximes to aldehydes and ketones catalyzed by a Br?nsted acid under mild conditions. Hydroxylamine salt, which necessitates a stoichiometric amount of base, was not required. NMR analysis clarified that this reaction proceeded through hydroxylamines generated by the successive hydrolysis of the oxime in situ. In addition, an environmentally benign method for catalytic transoximation was demonstrated in aqueous medium on a one hundred gram scale and the reaction filtrate containing the catalyst was recovered and reused over 10 times.

3-methyl-4-oxa-5-azahomoadamantane as an organocatalyst for the aerobic oxidation of primary amines to oximes in water

A simple and efficient catalytic system for the aerobic oxidation of primary amines into corresponding oximes has been developed, with 3-methyl-4-oxa-5-azahomoadamantane as catalyst, acetaldoxime as co-catalyst and water as solvent. This process, which uses oxygen (O2) as an economic and green oxidant and water as a green solvent, tolerates a wide range of substrates, affording the target oximes in moderate to excellent yields. It was found that high selectivity was achieved when 3-methyl-4-oxa-5-azahomoadamantane was used, and E-type oximes were the only detected products. A possible mechanism for this catalytic process is proposed.