37174-65-5

Basic information

• Product Name: 2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID
• Synonyms: 4'-BROMO-BIPHENYL-2-CARBOXYLIC ACID;2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID;4'-Bromo-1,1'-biphenyl-2-carboxylic acid
• CAS NO: 37174-65-5
• Molecular Formula: C₁₃H₉BrO₂
• Molecular Weight: 277.11
• Mol File: 37174-65-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 390 °C at 760 mmHg
• Flash Point: 189.6 °C
• Appearance: /
• Density: 1.51 g/cm³
• CAS DataBase Reference: 2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID(37174-65-5)
• EPA Substance Registry System: 2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID(37174-65-5)

Safety Data

• Hazardous Substances Data: 37174-65-5(Hazardous Substances Data)

Usage

General Description

2-Biphenyl-4'-bromo-carboxylic acid is a chemical compound with the molecular formula C14H9BrO2. It is a derivative of biphenyl, with a bromine atom attached to the 4' position of one of the phenyl rings and a carboxylic acid group attached to the other phenyl ring. 2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID is commonly used in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and dyes. It may also be used as a building block in the development of new materials and as a reagent in organic chemistry reactions. Additionally, 2-biphenyl-4'-bromo-carboxylic acid has been studied for its potential biological activities and may have applications in medicinal chemistry research.

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Downstream Products

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• 1026513-05-2 2-Butyl-6-chloro-3-{chloro-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methyl}-4,5-dimethyl-pyridine 
• 1026534-39-3 (2-Butyl-6-chloro-4,5-dimethyl-pyridin-3-yl)-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methanol 
• 153806-48-5 2-butyl-6-chloro-4-methyl-3-<<2'-(triphenylmethyltetrazol-5-yl)biphenyl-4-yl>hydroxymethyl>pyridine 
• 153806-49-6 2-butyl-6-chloro-4-methyl-3-<<2'-(triphenylmethyltetrazol-5-yl)biphenyl-4-yl>chloromethyl>pyridine 
• 1027315-18-9 (2-Butyl-4,5-dimethyl-pyridin-3-yl)-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methanol 
• 1026736-63-9 2-Butyl-3-{chloro-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methyl}-4,5-dimethyl-pyridine 
• 1025933-49-6 2-Butyl-3-{chloro-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methyl}-4-methyl-pyridine 
• 1027414-09-0 (2-Butyl-4-methyl-pyridin-3-yl)-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methanol 
• 1027371-83-0 2-Butyl-6-chloro-4,5-dimethyl-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-pyridine 
• 1027412-56-1 2-Butyl-6-chloro-4-methyl-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-pyridine 

Relevant articles and documents

Visible-Light-Induced Arene C(sp 2)-H Lactonization Promoted by DDQ and tert -Butyl Nitrite

A visible-light photocatalytic aerobic oxidative lactonization of arene C(sp 2)-H bonds proceeds in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert -butyl nitrite (TBN). Under the optimized conditions, a range of 2-arylbenzoic acids is converted into the corresponding benzocoumarin derivatives in moderate to excellent yields. This method is characterized by its atom economy, mild reaction conditions, the use of a green oxidant and metal-free catalysis.

Silver-Catalyzed C(sp2)-H Functionalization/C-O Cyclization Reaction at Room Temperature

Silver-catalyzed C(sp2)-H functionalization/C-O cyclization has been developed. The scalable reaction proceeds at room temperature in an open flask. The present method exhibits good functional-group compatibility because of the mild reaction conditions. Using a AgNO3 catalyst and a (NH4)2S2O8 oxidant in CH2Cl2/H2O solvent, various lactones are obtained in good to excellent yields. A kinetic isotope effect (KIE) study indicates that the reaction may occur via a radical process.

Pd-catalyzed C-H lactonization for expedient synthesis of biaryl lactones and total synthesis of cannabinol

A practical Pd(II)/Pd(IV)-catalyzed carboxyl-directed C-H activation/C-O cyclization to construct biaryl lactones has been developed. The synthetic utility of this new reaction was demonstrated in an atom-economical and operationally convenient total synthesis of the natural product cannabinol from commercially available starting materials, with the newly developed method used for two key steps.