37174-65-5

Usage

Uses

Used in Pharmaceutical Industry:
2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into complex molecular structures, potentially leading to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID is utilized as a building block in the creation of agrochemicals, such as pesticides and herbicides, due to its reactive functional groups that can be tailored for specific biological activities.
Used in Dye Industry:
2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID is employed as a precursor in the production of dyes, where its structural features contribute to the color and stability of the final dye products.
Used in Material Science:
As a component in the development of new materials, 2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID is used to enhance the properties of existing materials or to create novel materials with specific characteristics, such as improved conductivity or stability.
Used in Organic Chemistry Research:
In the realm of organic chemistry, 2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID serves as a reagent in various chemical reactions, facilitating the synthesis of a wide range of organic compounds for research and industrial applications.
Used in Medicinal Chemistry Research:
2-BIPHENYL-4'-BROMO-CARBOXYLIC ACID is studied for its potential biological activities, which may lead to its application in medicinal chemistry for the discovery and development of new therapeutic agents.

Upstream product

• 3096-56-8 2-bromofluoren-9-one 
• 17103-26-3 methyl 4'-bromo-[1,1'-biphenyl]-2-carboxylate 
• 5467-74-3 4-Bromophenylboronic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 106-37-6 1.4-dibromobenzene 
• 57598-33-1 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 84392-29-0 2-(4'-bromobiphenyl-2-yl)-4,4-dimethyloxazoline 

Downstream Products

• 105901-12-0 2-(4-bromophenyl)benzamide 
• 3096-56-8 2-bromofluoren-9-one 
• 408366-09-6 4-Bromo-2'-[(4-{(tert-butoxycarbonyl)[2-(2-pyridinyl)ethyl]amino}anilino)carbonyl]-1,1'-biphenyl 
• 1026513-05-2 2-Butyl-6-chloro-3-{chloro-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methyl}-4,5-dimethyl-pyridine 
• 1026534-39-3 (2-Butyl-6-chloro-4,5-dimethyl-pyridin-3-yl)-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methanol 
• 153806-48-5 2-butyl-6-chloro-4-methyl-3-<<2'-(triphenylmethyltetrazol-5-yl)biphenyl-4-yl>hydroxymethyl>pyridine 
• 153806-49-6 2-butyl-6-chloro-4-methyl-3-<<2'-(triphenylmethyltetrazol-5-yl)biphenyl-4-yl>chloromethyl>pyridine 
• 1027315-18-9 (2-Butyl-4,5-dimethyl-pyridin-3-yl)-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methanol 
• 1026736-63-9 2-Butyl-3-{chloro-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methyl}-4,5-dimethyl-pyridine 
• 1025933-49-6 2-Butyl-3-{chloro-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methyl}-4-methyl-pyridine 
• 1027414-09-0 (2-Butyl-4-methyl-pyridin-3-yl)-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl]-methanol 
• 1027371-83-0 2-Butyl-6-chloro-4,5-dimethyl-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-pyridine 
• 1027412-56-1 2-Butyl-6-chloro-4-methyl-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-pyridine 
• 1027030-59-6 2-Butyl-4,5-dimethyl-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-pyridine 

Relevant academic research and scientific papers

Visible-Light-Induced Arene C(sp 2)-H Lactonization Promoted by DDQ and tert -Butyl Nitrite

A visible-light photocatalytic aerobic oxidative lactonization of arene C(sp 2)-H bonds proceeds in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert -butyl nitrite (TBN). Under the optimized conditions, a range of 2-arylbenzoic acids is converted into the corresponding benzocoumarin derivatives in moderate to excellent yields. This method is characterized by its atom economy, mild reaction conditions, the use of a green oxidant and metal-free catalysis.

Vitamin Catalysis: Direct, Photocatalytic Synthesis of Benzocoumarins via (-)-Riboflavin-Mediated Electron Transfer

An operationally simple protocol is disclosed to facilitate entry to benzo-3,4-coumarins directly from biaryl carboxylic acids without the need for substrate prefunctionalization. Complementary to classic lactonization strategies, this disconnection relies on the oxidation competence of photoactivated (-)-riboflavin (vitamin B2) to generate the heterocyclic core via photoinduced single electron transfer. Collectively, the inexpensive nature of the catalyst, ease of execution, and absence of external metal additives are a convincing endorsement for the incorporation of simple vitamins in contemporary catalysis.

Silver-Catalyzed C(sp2)-H Functionalization/C-O Cyclization Reaction at Room Temperature

Silver-catalyzed C(sp2)-H functionalization/C-O cyclization has been developed. The scalable reaction proceeds at room temperature in an open flask. The present method exhibits good functional-group compatibility because of the mild reaction conditions. Using a AgNO3 catalyst and a (NH4)2S2O8 oxidant in CH2Cl2/H2O solvent, various lactones are obtained in good to excellent yields. A kinetic isotope effect (KIE) study indicates that the reaction may occur via a radical process.

Synthesis of fluorenones through rhodium-catalyzed intramolecular acylation of biarylcarboxylic acids

An efficient approach to the synthesis of fluorenones via the rhodium-catalyzed intramolecular acylation of biarylcarboxylic acids was developed. Using this procedure, fluorenones with various substituents can be synthesized in good to high yields. This work marks the first recorded use of catalytic intramolecular acylation to synthesize fluorenones.

Pd-catalyzed C-H lactonization for expedient synthesis of biaryl lactones and total synthesis of cannabinol

A practical Pd(II)/Pd(IV)-catalyzed carboxyl-directed C-H activation/C-O cyclization to construct biaryl lactones has been developed. The synthetic utility of this new reaction was demonstrated in an atom-economical and operationally convenient total synthesis of the natural product cannabinol from commercially available starting materials, with the newly developed method used for two key steps.

General and practical carboxyl-group-directed remote C-H oxygenation reactions of arenes

Two methods for remote aromatic C-H oxygenation reactions, have been developed. Method1, the Cu-catalyzed oxygenation reaction, is highly efficient for cyclization of electron-neutral and electron-rich biaryl carboxylic acids into 3,4-benzocoumarins. Method2, the K2S2O 8-mediated oxygenation reaction, is more general and practical for cyclization of substrates with electron-donating and -withdrawing groups (see scheme). Copyright

THIOPHENE AND FURAN COMPOUNDS

The present invention relates to thiophene and furan compounds and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression.

PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS

The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.

Nonpeptide angiotensin II receptor antagonists. I. Synthesis and biological activity of pyridine derivatives

Substituted pyridines were synthesized as potential angiotensin II (AII) receptor antagonists. Substitution at the position 2 in the pyridine resulted in potent activity, and the optimal alkyl length was four carbons. The potency further increased with the introduction of a hydroxymethyl group at the position 4. One of the compounds, 2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-[[2'-(1H-tetrazol-5-yl)bip henyl-4-yl]methyl]pyridine 9 h (KT3-579)is a competitive AII antagonist with a pA2 value of 9.31, and is about 10 times more potent than Du Pont 753. It was found to be an AT1 specific antagonist with an IC50 of 3.09 nM.

Biaryl aldehyde

This invention relates to a method of synthesis of certain substituted carboxylic acids useful in lowering serum triglyceride and total cholesterol levels in mammals (including man) represented by the general formula I: wherein Ar1 is selected from STR1 Ar2 is selected from STR2 and R is selected from C1-5 alkyl, halogen, perhalo-C1-4 alkyl, C1-4 alkoxy, phenyl, C1-4 acyl, C1-6 alkoxycarbonyl, amino or hydroxy.