371764-64-6

Basic information

• Product Name: QUINOLINE-4-BORONIC ACID
• Synonyms: RARECHEM AK VD 0024;QUINOLINE-4-BORONIC ACID;QUINOLIN-4-YLBORONIC ACID;QUINOLIN-4-BORANIC ACID;QUINOLIN-4-BORONIC ACID;4-QUINOLINYL-BORONIC ACID;Boronic acid, 4-quinolinyl- (9CI);Quinoline-4-boronicacid,97%
• CAS NO: 371764-64-6
• Molecular Formula: C₉H₈BNO₂
• Molecular Weight: 172.98
• EINECS: -0
• Product Categories: BORONICACID;pharmacetical;Heterocyclic Compounds;Boronic acid;Organoborons;Quinoline
• Mol File: 371764-64-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 400.3 °C at 760 mmHg
• Flash Point: 195.9 °C
• Appearance: /
• Density: 1.28
• Vapor Pressure: 3.99E-07mmHg at 25°C
• Refractive Index: 1.644
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 3.70±0.30(Predicted)
• CAS DataBase Reference: QUINOLINE-4-BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: QUINOLINE-4-BORONIC ACID(371764-64-6)
• EPA Substance Registry System: QUINOLINE-4-BORONIC ACID(371764-64-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38
• Safety Statements: 26-36/37/39-39-37
• Hazardous Substances Data: 371764-64-6(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

4-Quinolineboronic Acid is a reactant in the synthesis of NSC 12155, a small molecule inhibitor of anthrax lethal factor toxin.

InChI:InChI=1/C9H8BNO2/c12-10(13)8-5-6-11-9-4-2-1-3-7(8)9/h1-6,12-13H

Upstream product

• 121-43-7 Trimethyl borate 
• 3964-04-3 4-bromoquinoline 
• 5419-55-6 Triisopropyl borate 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1411985-81-3 potassium trifluoro(quinolin-4-yl)borate 
• 21233-61-4 quinoline-4-carboxylic acid methyl ester 

Relevant articles and documents

Nitrogen-containing compound, electronic element and electronic device

The invention provides a nitrogen-containing compound, an electronic component and an electronic device, and relates to the technical field of organic materials, wherein the nitrogen-containing compound is represented by a formula I, X is selected from oxygen and sulfur, R is selected from heterocycloalkyl and heteroaryl, L is selected from a single bond, arylene and heteroarylene, the substituentof R is selected from deuterium, nitro, hydroxyl, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, alkoxy, aryl silyl and alkyl silyl, and the substituent of L is selected from deuterium, nitro, hydroxyl, alkyl, cycloalkyl, alkenyl, alkynyl, heterocycloalkyl, alkoxy, alkylsilyl, arylsilyl, aryloxy and arylthio. The nitrogen-containing compound disclosed by the invention can reduce the working voltage of an electronic component, improve the efficiency of a device and prolong the service life of the device.

ISOQUINOLINES AS INHIBITORS OF HPK1

Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Substituted phenyl farnesyltransferase inhibitors

Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhibit farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.