371765-74-1Relevant articles and documents
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase
Curtin, Michael L.,Florjancic, Alan S.,Cohen, Jerome,Gu, Wen-Zhen,Frost, David J.,Muchmore, Steven W.,Sham, Hing L.
, p. 1367 - 1371 (2003)
A series of imidazole-containing biphenyls was prepared and evaluated in vitro for inhibition of FTase and cellular Ras processing. Several of these analogues, such as 21, are potent inhibitors of FTase (300-fold) and cellularly active (≤80 nM). An X-ray crystal structure of inhibitor 21 bound to rat farnesyltransferase is also presented.
Substituted phenyl farnesyltransferase inhibitors
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, (2012/09/25)
Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhibit farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
