371784-53-1

Basic information

• Product Name: Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1R,2R)- (9CI)
• Synonyms: Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1R,2R)- (9CI)
• CAS NO: 371784-53-1
• Molecular Formula: C₈H₁₂O₃
• Molecular Weight: 156.17908
• Product Categories: ALDEHYDE
• Mol File: 371784-53-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1R,2R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1R,2R)- (9CI)(371784-53-1)
• EPA Substance Registry System: Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1R,2R)- (9CI)(371784-53-1)

Safety Data

• Hazardous Substances Data: 371784-53-1(Hazardous Substances Data)

Upstream product

• 98515-98-1 (1R,2S)-cyclobutane-1,2-diylbis(methylene) diacetate 
• 54445-64-6 (1R,2S)-(2-hydroxymethylcyclobutyl)methanol 
• 4462-96-8 cis-1,2-cyclobutane dicarboxylic anhydride 
• 98516-06-4 ((1R,2S)-2-(hydroxymethyl)cyclobutyl)methyl acetate 
• 329010-17-5 Acetic acid (1R,2S)-2-formyl-cyclobutylmethyl ester 

Downstream Products

• 1883727-34-1 (1S,3’R,6’R,7’S,9’E,11’S,12’R)-6-chloro-7'-methoxy-11’,12’-dimethyl-3,4-dihydro-2H,15’H-spiro[naphthalene-1,22’-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.03,6.019,24]pentacosa[9,16,18,24]tetraen]-15’-one-13’,13'-dioxide 
• 1883727-34-1 (1S,3'R,6'R,7'S,8'Z,11'S,12'R)-6-chloro-7'-methoxy-11',12'-dimethyl-3,4-dihydro-2H,15'H-spiro[naphthalene-1,22'-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.0³'⁶.0¹⁹'²⁴]pentacosa[8,16,18,24]tetraen]-15'-one 13',13'-dioxide 

Relevant articles and documents

ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

COMPOUNDS THAT INHIBIT MCL-1 PROTEIN

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Cyclopropyl and cyclobutyl epothilone analogs

The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IV wherein Ar is a radical represented by the following structure: and the other radicals and symbols have the meanings as defined herein; to their