3718-22-7

Basic information

• Product Name: (Z)-(3-nitrophenyl)methylidenehydrazine
• Synonyms: (Z)-(3-nitrophenyl)methylidenehydrazine
• CAS NO: 3718-22-7
• Molecular Formula: C₇H₇N₃O₂
• Molecular Weight: 0
• Mol File: 3718-22-7.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 329.2°Cat760mmHg
• Flash Point: 152.9°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: (Z)-(3-nitrophenyl)methylidenehydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-(3-nitrophenyl)methylidenehydrazine(3718-22-7)
• EPA Substance Registry System: (Z)-(3-nitrophenyl)methylidenehydrazine(3718-22-7)

Safety Data

• Hazardous Substances Data: 3718-22-7(Hazardous Substances Data)

Usage

General Description

(Z)-(3-nitrophenyl)methylidenehydrazine is a chemical compound with a molecular formula of C7H7N3O2. It is a hydrazine derivative that is commonly used in organic synthesis and medicinal chemistry. It has a yellow color and is typically synthesized by reacting 3-nitrobenzaldehyde with hydrazine. The compound has been studied for its potential as a pharmaceutical intermediate and has shown promising results in anti-inflammatory and anti-cancer activities. However, it is important to handle this compound with caution as it poses potential hazards to human health and the environment.

InChI:InChI=1/C7H7N3O2/c8-9-5-6-2-1-3-7(4-6)10(11)12/h1-5H,8H2/b9-5+

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 5706-76-3 2-(3-nitrobenzylidene)hydrazinecarbothioamide 
• 5346-31-6 3-nitro-benzaldehyde semicarbazone 
• 109395-64-4 2-((3-nitrobenzylidene)amino)-1H-benzo[de]isoquinoline-1,3(2H)-dione 

Downstream Products

• 16246-64-3 m-Nitrobenzaldehyd-o-nitro-phenyl-semicarbazon 
• 40092-37-3 C₁₁H₁₄N₄O₃ 
• 40092-04-4 C₁₂H₁₆N₄O₃ 
• 65085-93-0 3-(2,2-dichloroethenyl)-nitrobenzene 
• 41097-40-9 3-nitrobenzaldehyde N-[-(3-nitrophenyl)methylidene]hydrazone 
• 6926-58-5 4,4-dimethylthiosemicarbazide 
• 2810-66-4 5-dimethylamino-1,3,4-thiadiazole-2-thiol 
• 1226600-30-1 C₉H₅F₄NO₂ 
• 114980-30-2 1-(2,2,2-trifluoroethyl)-3-nitrobenzene 

Relevant articles and documents

N-Amino-1,8-Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono-N-Substituted Hydrazines and Hydrazides

A new route to synthesis of various mono-N-substituted hydrazines and hydrazides by involving in a new C?N bond formation by using N-amino-1,8-naphthalimide as a regenerated precursor was invented. Aniline and phenylhydrazines are reproduced upon reacting these individually with 1,8-naphthalic anhydride followed by hydrazinolysis. The practicality and simplicity of this C?N dihalo alkanes; developed a synthon for bond formation protocol was exemplified to various hydrazines and hydrazides. N-amino-1,8-naphthalimide is suitable synthon for transformation for selective formation of mono-substituted hydrazine and hydrazide derivatives. Those are selective mono-amidation of hydrazine with acid halides; mono-N-substituted hydrazones from aldehydes; synthesis of N-aminoazacycloalkanes from acetohydrazide scaffold and inserted to hydroxy derivatives; distinct synthesis of N,N-dibenzylhydrazines and N-benzylhydrazines from benzyl halides; synthesis of N-amino-amino acids from α-halo esters. Ecofriendly reagent N-amino-1,8-naphthalimide was regenerated with good yields by the hydrazinolysis in all procedures.

Metal schiff base complexes of tridentate antipyrine based ligand: Synthesis, spectral characterisation, image analysis and biological studies

Novel tridentate antipyrine based ligand (L) were synthesized and characterized employing analytical, spectral and image processing techniques. The Co(II), Ni(II), Cu(II) and Zn(II) complexes of newly synthesized L is characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, FTIR, UV–visible, 1H NMR, 13C NMR, and mass spectrometry. Octahedral geometry is given to Co(II), Ni(II) and Zn(II) complexes, whereas Cu(II) complex preferred distorted octahedral geometry. The ligand to metal ratio was identified to be 1:1. Thermal stability of the new integrated compounds were inspected by thermogravimetric analysis. Porosity of the complexes is analysed by image processing. The electrochemical deportment of the Schiff base metal complexes was assessed using cyclic voltammetry. In vitro antimicrobial, DNA cleavage and SOD efficacy of the present compounds were determined. The in vitro anticancer potency of the metal complexes were also evaluated against Liver Bilobular cancerous cells (LBir2754).

Efficient Multigram Approach to Acetylenes and CF3-ynones Starting from Dichloroalkenes Prepared by Catalytic Olefination Reaction (COR)

A novel approach to terminal acetylenes based on catalytic olefination reaction COR of arylaldehydes to form dichloroalkenes followed by treatment with nBuLi was elaborated. This method is atom economical and displays high yields and effectivity. The corresponding alkynes can be prepared in up to 97 % yield. One pot procedure towards CF3-ynones was elaborated to provide these products in up to 87 % yield starting from dichloroalkenes.