371919-40-3Relevant academic research and scientific papers
Synthesis of phosphatase-stable, cell-permeable peptidomimetic prodrugs that target the SH2 domain of Stat3
Mandai, Pijus K.,Liao, Warren S.-L.,McMurray, John S.
supporting information; experimental part, p. 3394 - 3397 (2009/12/05)
The synthesis of prodrugs targeted to the SH2 domain of Stat3 is reported. Using a convergent strategy, the pivaloyloxymethyl phosphonodiester of pentachlorophenyl 4-phosphonodifluoromethylcinnamate, a phosphotyrosine surrogate, was synthesized and used t
Inhibitors of signal transduction and activator of transcription 3
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Page/Page column 8, (2010/11/25)
Stat3 inhibitor compounds are disclosed, wherein the compounds are structural analogs of Ac-pTyr-Leu-Pro-Gln-Thr-NH2 and bind to the SH2 domain of Stat3 under physiological conditions to inhibit a cellular signaling activity of Stat3.
