371943-05-4 Usage
Description
PI3-Kinase α Inhibitor 2 is a potent and selective inhibitor of PI3K p110α, a key enzyme involved in cellular signaling pathways. With an IC50 of 2 nM in an enzyme assay, it demonstrates high specificity for p110α over other isoforms such as p110β, p110γ, and PI3K C2β. Additionally, it exhibits inhibitory effects on mammalian target of rapamycin (mTOR) with an IC50 of 49 nM. PI3-Kinase α Inhibitor 2 has been shown to effectively inhibit proliferation in A375 melanoma cells, with an IC50 value of 0.58 μM.
Uses
Used in Pharmaceutical Industry:
PI3-Kinase α Inhibitor 2 is used as a therapeutic agent for targeting cancer cell proliferation. Its high selectivity for p110α and inhibitory effects on mTOR make it a promising candidate for the development of cancer treatments, particularly for melanoma.
Used in Research Applications:
In the field of biological research, PI3-Kinase α Inhibitor 2 serves as a valuable tool for studying the roles of PI3K p110α and mTOR in cellular processes. It can be employed to investigate the mechanisms underlying cancer cell proliferation and the potential of targeting these pathways for therapeutic intervention.
Used in Drug Development:
PI3-Kinase α Inhibitor 2 is utilized in the development of novel drugs targeting the PI3K/AKT/mTOR signaling pathway, which is often dysregulated in various types of cancer. Its potent and selective inhibition of p110α and mTOR can guide the design of more effective and targeted cancer therapies.
Used in Combination Therapy:
PI3-Kinase α Inhibitor 2 can be explored for its potential synergistic effects when combined with other chemotherapeutic agents. This may enhance the efficacy of existing treatments and overcome resistance in certain cancer cases, providing a new avenue for cancer therapy development.
Check Digit Verification of cas no
The CAS Registry Mumber 371943-05-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,1,9,4 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 371943-05:
(8*3)+(7*7)+(6*1)+(5*9)+(4*4)+(3*3)+(2*0)+(1*5)=154
154 % 10 = 4
So 371943-05-4 is a valid CAS Registry Number.
