371945-06-1

Basic information

• Product Name: Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
• Synonyms: Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI);Furo[2,3-b]pyridine-2-carboxylicacid,3-amino-, ethyl ester;ethyl 3-amino furo[2,3-b]pyridine-2-carboxylate;3-Amino-furo[2,3-b]pyridine-2-carboxylic acid ethyl ester;3-aminofuro[2,3-b]pyridine-2-carboxylate;Ethyl 3-aminofuro[2,3-B]pyridine-2-carboxylate ,98%;ethyl 2-aminofuro[2,3-b]pyridine-3-carboxylate
• CAS NO: 371945-06-1
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.198
• Product Categories: AMINOACID;Heterocycle-Pyridine series
• Mol File: 371945-06-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 134 °C
• Boiling Point: 342 °C at 760 mmHg
• Flash Point: 160.6 °C
• Appearance: /
• Density: 1.319 g/cm³
• Vapor Pressure: 7.75E-05mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.22±0.40(Predicted)
• CAS DataBase Reference: Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)(371945-06-1)
• EPA Substance Registry System: Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)(371945-06-1)

Safety Data

• Hazardous Substances Data: 371945-06-1(Hazardous Substances Data)

Usage

General Description

Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) is a chemical compound with the molecular formula C10H10N2O3. It is an ethyl ester derivative of furo[2,3-b]pyridine-2-carboxylic acid, which is a heterocyclic compound. This chemical is commonly used in the synthesis of pharmaceutical drugs and as a building block in organic chemistry. It may also have applications in research and development for the creation of new drugs and materials. However, as with any chemical compound, safety precautions should be taken when handling and using furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) to prevent potential harm to human health and the environment.

InChI:InChI=1/C10H10N2O3/c1-2-14-10(13)8-7(11)6-4-3-5-12-9(6)15-8/h3-5H,2,11H2,1H3

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 623-50-7 ethyl 2-hydroxyacetate 

Downstream Products

• 940004-31-9 C₁₇H₁₃N₃O₆ 
• 371943-69-0 ethyl 3-(3-methoxybenzamido)furo[2,3-b]pyridine-2-carboxylate 
• 940004-30-8 C₁₇H₁₄N₂O₄ 
• 1235181-59-5 pyrido[3',2':4,5]furo[3,2-d]pyrimidine-2,4(1H,3H)-dione 
• 1509919-82-7 ethyl 3-(3-methoxy-5-(trifluoromethyl)benzamido)furo[2,3-b]pyridine-2-carboxylate 
• 1509919-81-6 ethyl 3-(3-methoxy-5-methylbenzamido)furo[2,3-b]pyridine-2-carboxylate 
• 1509919-80-5 ethyl 3-(3-methoxy-5-nitrobenzamido)furo[2,3-b]pyridine-2-carboxylate 
• 1509919-79-2 ethyl 3-(3,5-dimethoxybenzamido)furo[2,3-b]pyridine-2-carboxylate 
• 1509919-78-1 ethyl 3-(3-bromo-5-methoxybenzamido)furo[2,3-b]pyridine-2-carboxylate 
• 1509919-77-0 ethyl 3-(3-chloro-5-methoxybenzamido)furo[2,3-b]pyridine-2-carboxylate 
• 1509919-76-9 ethyl 3-(3-fluoro-5-methoxybenzamido)furo[2,3-b]pyridine-2-carboxylate 

Relevant articles and documents

FUSED PYRIMIDINES AS ISOFORM SELECTIVE PHOSPHOINOSITIDE-3-KINASE-ALPHA INHIBITORS AND PROCESS FOR PREPARATION THEREOF

The present invention relates to fused pyrimidines of formulae I and II wherein, R1, R2 are as herein described. The present invention particularly relates to isoform selective PI3Kα inhibition and their medicinal use as anticancer agents.

TRICYCLIC HETEROCYCLIC COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS

Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N-H, N-(C1-C10 alkyl) or S; each X is independently CH or N; R1 is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R2 is (LQ)mY; and each R3 is independently H, C1-C10 alkyl, aryl or heteroaryl, are surprisingly found to be inhibitors of PI3K-p110δ, and therefore have utility in therapy.

Straightforward access to ethyl 3-aminofuropyridine-2-carboxylates from 1-chloro-2-cyano- or 1-hydroxy-2-cyano-substituted pyridines

The conditions of the synthesis of the four regioisomers of ethyl 3-aminofuropyridine-2-carboxylate are described and discussed in detail. The starting materials are either 1-chloro-2-cyanopyridines or 1-cyano-2- hydroxypyridines. Georg Thieme Verlag Stuttgart.