372-22-5 Usage
Uses
Used in Pharmaceutical Industry:
5,5,5-TRIFLUORO-DL-LEUCINE is used as a chiral building block for the synthesis of pharmaceuticals, contributing to the development of novel drugs with improved efficacy and selectivity. Its unique structure allows for the creation of enantiomerically pure compounds, which is crucial for the production of drugs with fewer side effects and higher potency.
Used in Agrochemical Industry:
In the agrochemical sector, 5,5,5-TRIFLUORO-DL-LEUCINE is utilized as a key component in the synthesis of new agrochemicals, including pesticides and herbicides. Its incorporation can enhance the performance of these products, potentially leading to more effective and environmentally friendly agricultural solutions.
Used in Drug Design and Development:
5,5,5-TRIFLUORO-DL-LEUCINE is employed in drug design and development as a precursor for the creation of innovative antimicrobial and antifungal agents. Its unique properties enable the design of new molecules with improved activity against resistant strains of bacteria and fungi, addressing the growing need for effective treatments in the face of antibiotic and antifungal resistance.
Used in Fine Chemicals Synthesis:
5,5,5-TRIFLUORO-DL-LEUCINE is also used as a building block in the synthesis of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, flavors, and specialty materials. The introduction of fluorine atoms in 5,5,5-TRIFLUORO-DL-LEUCINE can lead to the development of new fine chemicals with unique properties and applications.
Overall, 5,5,5-TRIFLUORO-DL-LEUCINE's unique structure and properties have made it a valuable asset in the scientific and industrial communities, with potential applications spanning across various fields, including drug discovery, pharmaceuticals, agrochemicals, and fine chemicals synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 372-22-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,7 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 372-22:
(5*3)+(4*7)+(3*2)+(2*2)+(1*2)=55
55 % 10 = 5
So 372-22-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H10F3NO2/c1-3(6(7,8)9)2-4(10)5(11)12/h3-4H,2,10H2,1H3,(H,11,12)
372-22-5Relevant academic research and scientific papers
New and Effective Routes to Fluoro Analogues of Aliphatic and Aromatic Amino Acids
Ojima, Iwao,Kato, Koji,Nakahashi, Kazuaki,Fuchikami, Takamasa,Fujita, Makoto
, p. 4511 - 4522 (2007/10/02)
New and efficient syntheses of 4,4,4-trifluorovaline (1), 5,5,5-trifluoronorvaline (2), 5,5,5-trifluoroleucine (5), 6,6,6-trifluoronorleucine (6), 4,5,6,7-tetrafluorotryptophan (25), and α-(trifluoromethyl)-β-alanine are studied.Trifluorovaline (1) and trifluoronorvaline (2) are synthesized through amidocarbonylation of 2-(trifluoromethyl)propanal (2-TFMPA) and 3-(trifluoromethyl)propanal (3-TFMPA), respectively, followed by hydrolysis.Trifluoroleucine (5) and trifluoronorleucine (6) are synthesized by using modified Erlenmeyer's azlactone method from 2-TFMPA and 3-TFMPA, respectively. (S)- and (R)-trifluoronorvalines and trifluoronorleucines with high enantiomeric purities (95-100percent ee) are obtained through enzymatic optical resolution of N-acetyltrifluoronorvaline (4) and N-acetyltrifluoronorleucine (17) with the use of a porcine kidney acylase I.Optically active trifluoronorleucine is also obtained via the asymmetric hydrogenation of (Z)-N-benzoyldehydrotrifluoroleucine ethyl ester (10a-Z) with a chiral rhodium catalyst, ClO4, followed by hydrolysis.Unexpectedly high diastereoselectivities (80-87percent ee) are observed in the hydrogenation of (Z)-N-benzoyldehydrotrifluoroleucine ethyl ester (11b) and (Z)-N-benzoyl-4-(pentafluorophenyl)dehydronorvaline (14-Z) over palladium/carbon. 4,5,6,7-Tetrafluorotryptophan (25) and 4,5,6,7-tetrahydrotryptamine (30) are synthesized from 3-formyl-4,5,6,7-tetrafluoroindole (22a) in 51percent (four steps) and 83percent (two steps) overall yields, respectively. 4,5,6,7-Tetrafluoroindoleacetic acid (28) is obtained from 1-acetyl-3-(acetoxymethyl)-4,5,6,7-tetrafluoroindole (23a) in four steps in 65percent overall yield.The 3-formyl- and 1-acetyl-3-(acetoxymethyl)tetrafluoroindoles (22a, 23a) are prepared through selenium dioxide oxidation of 1-acyl-3-methyl-4,5,6,7-tetrafluoroindole (21), which is obtained via the cyclization of a Schiff base of 2-(pentafluorophenyl)propanal (2-PFPPA), in good yields.
