372120-51-9

Basic information

• Product Name: (3-Amino-4-(trifluoromethyl)phenyl)methanol
• Synonyms: (3-Amino-4-(trifluoromethyl)phenyl)methanol
• CAS NO: 372120-51-9
• Molecular Formula: C₈H₈F₃NO
• Molecular Weight: 191.1504296
• Mol File: 372120-51-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (3-Amino-4-(trifluoromethyl)phenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Amino-4-(trifluoromethyl)phenyl)methanol(372120-51-9)
• EPA Substance Registry System: (3-Amino-4-(trifluoromethyl)phenyl)methanol(372120-51-9)

Safety Data

• Hazardous Substances Data: 372120-51-9(Hazardous Substances Data)

Usage

General Description

(3-Amino-4-(trifluoromethyl)phenyl)methanol is a chemical compound with the molecular formula C8H8F3NO. It is an organic compound and can be used in various applications, such as in the production of pharmaceuticals, agrochemicals, and specialty chemicals. (3-Amino-4-(trifluoromethyl)phenyl)methanol has a trifluoromethyl group attached to a phenyl ring, which contributes to its reactivity and potential use in synthetic chemistry. It also contains an amino group and a hydroxyl group, making it a versatile building block for the synthesis of complex molecules. Additionally, the trifluoromethyl group can influence the compound's properties, such as its solubility and stability, making it valuable in different chemical processes. Overall, (3-Amino-4-(trifluoromethyl)phenyl)methanol is a multifunctional compound with potential applications in various fields of chemistry and industry.

Upstream product

• 116965-16-3 3-nitro-4-(trifluoromethyl)benzoic acid 
• 372119-86-3 [3-nitro-4-(trifluoromethyl)phenyl]methanol 
• 455-24-3 4-trifluoromethylbenzoic acid 

Downstream Products

• 372120-54-2 3-bromo-4-trifluoromethylphenyl methanol 
• 372120-52-0 [3-iodo-4-(trifluoromethyl)phenyl]methanol 
• 372120-55-3 3-bromo-4-(trifluoromethyl)benzaldehyde 

Relevant articles and documents

Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinoline-8(4H)-one 1,1-dioxide K ATP channel openers: Discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b] quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent KATP opener that selectively inhibits spontaneous bladder contractions

Structure-activity relationships were investigated on a novel series of sulfonyldihydropyridine-containing KATP openers. Ring sizes, absolute stereochemistry, and aromatic substitution were evaluated for K ATP activity in guinea pig bladder cells using a fluorescence-based membrane potential assay and in a pig bladder strip assay. The inhibition of spontaneous bladder contractions in vitro was also examined for a select group of compounds. All compounds studied showed greater potency to inhibit spontaneous bladder contractions relative to their potencies to inhibit contractions elicited by electrical stimulation. In an anesthetized pig model of myogenic bladder overactivity, compound 14 and (-)-cromakalim 1 were found to inhibit spontaneous bladder contractions in vivo at plasma concentrations lower than those that affected hemodynamic parameters. Compound 14 showed approximately 5-fold greater selectivity than 1 in vivo and supports the concept that bladder-selective KATP channel openers may have utility in the treatment of overactive bladder.

Novel radioligands and their use for identifying potassium channel modulators

The present invention relates to novel radioligands and test methods using those radioligands in screening compounds.