372120-65-5

Basic information

• Product Name: 2H-Pyran-3(6H)-one,5-amino-6-methyl-(9CI)
• Synonyms: 2H-Pyran-3(6H)-one,5-amino-6-methyl-(9CI)
• CAS NO: 372120-65-5
• Molecular Formula: C₆H₉NO₂
• Molecular Weight: 127.14116
• Product Categories: AMINEPRIMARY
• Mol File: 372120-65-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-Pyran-3(6H)-one,5-amino-6-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-3(6H)-one,5-amino-6-methyl-(9CI)(372120-65-5)
• EPA Substance Registry System: 2H-Pyran-3(6H)-one,5-amino-6-methyl-(9CI)(372120-65-5)

Safety Data

• Hazardous Substances Data: 372120-65-5(Hazardous Substances Data)

Upstream product

• 359867-44-0 methyl [(1-methyl-2-propynyl)oxy]acetate 
• 359867-45-1 methyl (1-methyl-2-oxopropoxy)acetate 
• 359867-46-2 2-methyl-2H-pyran-3,5-(4H,6H)-dione 
• 372120-63-3 5-ethoxy-6-methyl-2H-pyran-3(6H)-one 

Downstream Products

• 372120-66-6 methyl 4-(3-bromo-4-fluorophenyl)-2,8-dimethyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate 

Relevant articles and documents

Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2, 6-dioxa-4-azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener

Structure-activity relationships were investigated on the tricyclic dihydropyridine (DHP) KATP openers 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H- 2,6-dioxa-4-azacyclopenta[b]naphthalene-1,8-dione (6) and 10-(3-bromo-4- fluorophenyl)-9,10-dihydro-1H,8H-2,7-dioxa-9-azaanthracene-4,5-dione (65). Substitution off the core of the DHP, absolute stereochemistry, and aromatic substitution were evaluated for KATP channel activity using Ltk- cells stably transfected with the Kir6.2/SUR2B exon 17- splice variant and in an electrically stimulated pig bladder strip assay. A select group of compounds was evaluated for in vitro inhibition of spontaneous bladder contractions. Several compounds were found to have the unique characteristic of partial efficacy in both the cell-based and electrically stimulated bladder strip assays but full efficacy in inhibiting spontaneous bladder strip contractions. For compound 23b, this profile was mirrored in vivo where it was fully efficacious in inhibiting spontaneous myogenic bladder contractions but only partially able to reduce neurogenically mediated reflex bladder contractions.