FACTOR D, HUMAN, also known as complement factor D, is a serine protease enzyme that plays a crucial role in the activation of the alternative pathway in the complement system. It is involved in the immune response and helps to protect the body against infections and diseases. The enzyme undergoes a self-inhibitory loop that switches it from a resting to an active state. Recent research has also linked a single nucleotide polymorphism (SNP) rs3826945 in the complement factor D gene with age-related macular degeneration (AMD), where there is a significant increase in plasma complement factor D concentration.
37213-56-2
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Basic information
- Product Name: FACTOR D, HUMAN
- Synonyms: ADIPSIN;ADIPSIN, HUMAN;COMPLEMENT FACTOR D;FACTOR D, HUMAN;C3 ACTIVATOR CONVERTASE;C3 ACTIVATOR CONVERTASE, HUMAN;complement factor D from human plasma
- CAS NO:37213-56-2
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: Complement Factor ProteinsEnzymes, Inhibitors, and Substrates;Complement Proteins;ComplementCell Signaling Enzymes;Plasma&Blood Proteins;Plasma, Blood, and Related Proteins and Reagents;Proteolytic Enzymes;Proteolytic Enzymes and Substrates
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: CLEAR COLORLESS LIQUID
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −70°C
- Solubility: N/A
- CAS DataBase Reference: FACTOR D, HUMAN(CAS DataBase Reference)
- NIST Chemistry Reference: FACTOR D, HUMAN(37213-56-2)
- EPA Substance Registry System: FACTOR D, HUMAN(37213-56-2)
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Safety Data
- Hazard Codes: B
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 37213-56-2(Hazardous Substances Data)
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37213-56-2 Usage
Uses
Used in Medical Research:FACTOR D, HUMAN is used as a research subject for understanding the role of the complement system in the immune response and its involvement in various diseases, including age-related macular degeneration (AMD). The study of the self-inhibitory loop and the SNP rs3826945 helps in understanding the mechanisms of the enzyme's activation and its association with AMD.
Used in Drug Development:
FACTOR D, HUMAN is used as a target for drug development to treat age-related macular degeneration (AMD) and other diseases associated with the complement system. By modulating the activity of complement factor D, it may be possible to develop therapies that can reduce the risk of AMD and other complement-related diseases.
Used in Diagnostics:
FACTOR D, HUMAN can be used as a biomarker for diagnosing age-related macular degeneration (AMD) and monitoring the progression of the disease. The measurement of plasma complement factor D concentration can help in identifying individuals at risk and assessing the effectiveness of treatments.
Used in Immunology:
FACTOR D, HUMAN is used in immunology research to study the role of the complement system in the immune response and its interaction with other components of the immune system. Understanding the function of complement factor D can provide insights into the development of new immunotherapies and vaccines.
Biochem/physiol Actions
Complement factor D is a serine protease with structural homologies with chymotrypsin. In the complement cascade, factor D cleaves complement factor B in complex with activated complement component C3. It is identical to adipsin, which is expressed in adipose tissue.Check Digit Verification of cas no
The CAS Registry Mumber 37213-56-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,2,1 and 3 respectively; the second part has 2 digits, 5 and 6 respectively.Calculate Digit Verification of CAS Registry Number 37213-56:
(7*3)+(6*7)+(5*2)+(4*1)+(3*3)+(2*5)+(1*6)=102
102 % 10 = 2
So 37213-56-2 is a valid CAS Registry Number.
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FACTOR D, HUMAN
