372162-76-0Relevant academic research and scientific papers
Synthesis of 1-Alkyl-5-amino-1,2,4-triazoles Based on Nucleophilic Substitution and Reduction Reactions
Tolstyakov
, p. 1537 - 1547 (2018)
A series of 1-alkyl-5-amino-1H-1,2,4-triazoles were synthesized starting from 3,5-dibromo-1H- 1,2,4-triazole by alkylation and subsequent nucleophilic substitution of the 5-bromine atom by azido group, reduction of the latter to amino group, and hydrodebromination.
SSAO INHIBITOR
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Paragraph 0392; 0393; 0394, (2020/04/02)
The present invention provides an SSAO inhibitor and an application thereof in preparing a drug for treating a disease related to SSAO. In particular, the present invention provides a compound shown in formula (IV) and a pharmaceutically acceptable salt thereof.
NOVEL COMPOUNDS
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Page/Page column 233, (2019/11/19)
The present invention relates to substituted 5-membered nitrogen containing heteroaryl compounds, such as sulfonyl triazoles, where the heteroaryl ring is further substituted, optionally via a linking group such as -NH-, with a cyclic group which in turn is substituted at the α-position. The present invention further relates to associated salts, solvates, prodrugs and pharmaceutical compositions, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.
TRIAZOLE COMPOUNDS AS ANTIVIRALS
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Paragraph 0308, (2014/01/18)
The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
ANTIVIRAL COMPOUNDS
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Page/Page column 50; 51, (2014/09/29)
The present invention discloses compounds of Formula I wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the pre
TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS
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Page/Page column 52; 53, (2014/01/07)
The present invention provides compounds of formula (Ia) and (Ib) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.
Thieno[2,3-d]pyrimidinediones and their use as pharmaceuticals
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, (2008/06/13)
The invention provides thieno[2,3-d]pyrimidinediones of general formula (I), wherein R, R1, R2 and R3 are as defined in the specification, processes for their production, pharmaceutical compositions containing them and the
