3722-71-2

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General Description

6-Chloro-3,4-dihydro-2H-chromene is a chemical compound with the molecular formula C9H9ClO. It is a chlorinated derivative of chromene, which is a heterocyclic compound containing a benzene ring fused to a pyran ring. 6-chloro-3,4-dihydro-2H-chroMene has potential applications in pharmaceuticals and agrochemicals, as it exhibits various biological activities such as antioxidant, anticancer, and anti-inflammatory properties. The chloro substitution at the 6-position of the chromene ring may modulate its biological activity, making it a valuable target for further research and development. Additionally, it can be used as a building block for the synthesis of other functionalized chromene derivatives with diverse chemical and biological properties.

InChI:InChI=1/C9H9ClO/c10-8-3-4-9-7(6-8)2-1-5-11-9/h3-4,6H,1-2,5H2

Upstream product

• 22991-03-3 3-(3-chlorophenyl)propanol 
• 76429-75-9 2-Bromo-1-(3-bromo-propoxy)-4-chloro-benzene 

Relevant academic research and scientific papers

Benzene C-H Etherification via Photocatalytic Hydrogen-Evolution Cross-Coupling Reaction

Aryl ethers can be constructed from the direct coupling between the benzene C-H bond and the alcohol O-H bond with the evolution of hydrogen via the synergistic merger of photocatalysis and cobalt catalysis. Utilizing the dual catalyst system consisting of 3-cyano-1-methylquinolinum photocatalyst and cobaloxime, intermolecular etherification of arenes with various alcohols and intramolecular alkoxylation of 3-phenylpropanols with formation of chromanes are accomplished. These reactions proceed at remarkably mild conditions, and the sole byproduct is equivalent hydrogen gas.

Hypoglycemic 5-substituted oxazolidine-2,4-diones

Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2,4-diones and the pharmaceutically acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.

Oxygen Heterocycles by the Parham Cyclialkylation

The addition of butyllithium at -100 deg C to ω-bromoalkyl ethers of o-bromophenol (and its congeners) led to preferential exchange of the aryl bromine at position 2.The resulting organolithium reagents, under suitable conditions, cyclized to afford 2,3-dihydrobenzofurans (6), 3,4-dihydro-2H-1-benzopyrans (13), or 2,3,4,5-tetrahydro-1-benzoxepins (16) in good yields, but less satisfactory results were obtained with the intermediate expected to produce 8-methyl-3,4,5,6-tetrahydro-2H-1-benzoxocin (19). ω-Bromoethyl and ω-bromopropyl ethers of suitable dibromophenols were treated successively with 2 equiv of butyllithium and an electrophile to yield derivatives of 6 and 13.