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Notexin is a potent neurotoxin derived from the venom of the Australian tiger snake (Notechis scutatus), characterized by its presynaptic action on the nervous system, leading to paralysis and potentially respiratory failure due to its phospholipase A2 (PLA2) enzyme component that disrupts cell membranes and synaptic transmission.

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  • 37223-96-4 Structure
  • Basic information

    1. Product Name: NOTEXIN
    2. Synonyms: NOTEXIN;notexin from notechis scutatus scutatus;Notechia scutatus notexin;Notexin (notechia scutatus);Phospholipase (notechia scutatus);Snake toxins;NOTEXIN Np & Ns;Notexine Np
    3. CAS NO:37223-96-4
    4. Molecular Formula:
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 37223-96-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: −20°C
    8. Solubility: N/A
    9. CAS DataBase Reference: NOTEXIN(CAS DataBase Reference)
    10. NIST Chemistry Reference: NOTEXIN(37223-96-4)
    11. EPA Substance Registry System: NOTEXIN(37223-96-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS: RD3800000
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 37223-96-4(Hazardous Substances Data)

37223-96-4 Usage

Uses

Used in Pharmaceutical Research:
Notexin is used as a research tool for studying the effects of neurotoxins on the nervous system and neuromuscular function. Its ability to cause paralysis and disrupt neurotransmitter release makes it valuable for understanding the mechanisms of action of various toxins and developing potential treatments for neurological disorders.
Used in Drug Development:
Notexin is utilized in the development of drugs targeting the nervous system, particularly for conditions involving neuromuscular dysfunction. Its mechanism of action provides insights into the design of therapeutic agents that can modulate neurotransmission and alleviate symptoms associated with neuromuscular disorders.
Used in Venom Antivenom Production:
Notexin is used in the production of antivenom for the Australian tiger snake, providing a critical treatment for individuals bitten by this venomous snake. The antivenom neutralizes the toxic effects of Notexin, preventing paralysis and respiratory failure, and supporting the recovery of affected individuals.
Used in Forensic Toxicology:
Notexin is employed in forensic toxicology for the analysis and identification of venom components in cases of poisoning or envenomation. Its unique properties and effects on the nervous system make it a distinctive marker for forensic investigations involving snake venom.
Used in Neurobiological Studies:
Notexin is used as a neurobiological research tool to explore the complexities of synaptic transmission and neuromuscular function. Its impact on neurotransmitter release and muscle weakness provides valuable information on the underlying processes of neuromuscular disorders and potential therapeutic interventions.

Check Digit Verification of cas no

The CAS Registry Mumber 37223-96-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,2,2 and 3 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 37223-96:
(7*3)+(6*7)+(5*2)+(4*2)+(3*3)+(2*9)+(1*6)=114
114 % 10 = 4
So 37223-96-4 is a valid CAS Registry Number.

37223-96-4Upstream product

37223-96-4Downstream Products

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