372514-07-3Relevant academic research and scientific papers
Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: Novel and selective histamine H3 receptor antagonists
Faghih, Ramin,Dwight, Wesley,Pan, Jia Bao,Fox, Gerard B.,Krueger, Kathy M.,Esbenshade, Timothy A.,McVey, Jill M.,Marsh, Kennan,Bennani, Youssef L.,Hancock, Arthur A.
, p. 1325 - 1328 (2003)
Novel 4′-[(NR1R2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at histamine H3receptors. Most compounds were highly potent and selective for human and rat H3 receptors and selected examples such as A-349821 showed functional antagonism of H3 receptors in vitro and in a mouse dipsogenia model.
Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
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, (2008/06/13)
Compounds of formula (I) are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands.
Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
-
, (2008/06/13)
Compounds of formula (I) are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands.
