3727-17-1

Upstream product

• 3727-20-6 2-allyloxy-1,4-dimethylbenzene 
• 75-24-1 trimethylaluminum 
• 95-87-4 2,5-Dimethylphenol 
• 91-66-7 N,N-diethylaniline 

Downstream Products

• 126734-05-2 5-Chloro-4,7-dimethyl-2-phenylsulfanylmethyl-2,3-dihydro-benzofuran 
• 126734-06-3 5-Chloro-4,6-dimethyl-2-phenylsulfanylmethyl-2,3-dihydro-benzofuran 
• 126707-91-3 4,7-dimethyl-2-(phenylthiomethyl)-2,3-dihydrobenzofuran 
• 126708-20-1 4,7-dimethyl-5-(phenylthio)-2-(phenylthiomethyl)-2,3-dihydrobenzofuran 
• 126707-92-4 4,6-dimethyl-2-(phenylthiomethyl)-2,3-dihydrobenzofuran 
• 126708-21-2 4,6-dimethyl-5-(phenylthio)-2-(phenylthiomethyl)-2,3-dihydrobenzofuran 

Relevant academic research and scientific papers

INDOLINE DERIVATIVES

Compounds of Formula (I) are disclosed and methods of treating viral infections with compositions comprising such compounds.

Water-Accelerated Tandem Claisen Rearrangement-Catalytic Asymmetric Carboalumination

matrix presented The addition of stoichiometric quantities of water accelerates both the trimethylaluminum-mediated aromatic Claisen reaction and the chiral zirconocene-catalyzed asymmetric carboalumination of terminal alkenes. The two reactions occur in a tandem sequence resulting in the selective formation of two new C-C and one C-O bond after oxidative quench of the intermediate trialkylalane.

Alternative Lewis acids to effect Claisen rearrangement

Yb(OTf)3 and DIBAL-H are developed as alternative Lewis acids for effecting Claisen rearrangement of allyl, crotyl and prenyl aryl ethers.

Synthesis of methyl 2,3-dihydro-2-benzofurancarboxylates from o-allylphenols via 2-(phenylthiomethyl)-2,3-dihydrobenzofurans

A method for synthesizing methyl 2,3-dihydro-2-benzofurancarboxylates rom o-allylphenols is described.The reaction of 6allyl-2,3-dichlorophenol (3) with benzenesulfenyl chloride (PhSCl) in acetonitrile gave a mixture of PhSCl -adducts, which was heated in aqueous acetonitrile then with sodium bicarbonate to obtain 6,7-dichloro-2-(phenylmethyl)-2,3-dihydrobenzofuran (6). α-Dichlorination of the phenylthiomethyl group of 6 and subsequent methanolysis gave the methyl ester 5 in high yield.The generality of this synthetic method was examined by the conversion of o-allylphenols 11 having various substituents on the benzene ring into the corresponding methyl ester 23.Cyclization of 11 to sulfides 12 could be achived similerly to the case of 3.However, in the subsequent conversions of 12 to 23, selective α-dichlorination followed by methanolysis could be achived only with 12 substituted with an electron-withdrawing group such as a chloro or nitro group.Keywords - oallylphenils; methyl 2,3-dihydro-2-benzofurancarboxylate; 2-(phenylthiomethyl)-2,3-dihydrobenzofuran; benzenesulfenyl chloride; α-chlorination; methanolysis.

929. Chrom-3-en-6-ols. The action of pyridine on alk-2-enyl-benzoquinones

Allylbenzoquinones are converted by treatment with pyridine into quinols and chrom-3-en-6-ols. The tendency for the latter reaction to occur increases as the benzoquinone ring becomes more highly substituted.