372941-54-3 Usage
Uses
Used in Pharmaceutical Industry:
3-Oxo Citalopram is used as a key intermediate in the synthesis of Citalopram and Escitalopram for their antidepressant properties. These medications are prescribed to treat major depressive disorder and other mood disorders, providing relief to patients suffering from these conditions.
Used as Escitalopram EP Impurity C:
In addition to its role as an intermediate, 3-Oxo Citalopram is also utilized as an impurity reference substance in the European Pharmacopeia (EP) for Escitalopram. This application ensures the quality control and standardization of Escitalopram, a widely used antidepressant, by providing a reference point for the identification and quantification of impurities in the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 372941-54-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,2,9,4 and 1 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 372941-54:
(8*3)+(7*7)+(6*2)+(5*9)+(4*4)+(3*1)+(2*5)+(1*4)=163
163 % 10 = 3
So 372941-54-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H19FN2O2/c1-23(2)11-3-10-20(15-5-7-16(21)8-6-15)18-9-4-14(13-22)12-17(18)19(24)25-20/h4-9,12H,3,10-11H2,1-2H3
372941-54-3Relevant academic research and scientific papers
Preparation method of citalopram impurities
-
Paragraph 0025; 0034-0037, (2021/03/31)
The invention relates to a preparation method of a citalopram impurity. The preparation method comprises the following steps: oxidizing free 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxybutyl]-3-hydroxymethyl benzonitrile hydrobromide and a Jones reagent to prepare a citalopram impurity C; and carrying out a reduction reaction with DIBAL-H by using the citalopram impurity C asa raw material to prepare a citalopram impurity B, wherein the citalopram impurity B is 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-3-hydroxy-1,3-dihydro-5-nitrile isobenzofuran. According to the invention, the citalopram impurity can be stably obtained at high yield, so that a basis is provided for qualitative and quantitative determination of the impurity in a raw material medicine synthesisprocess.
