372986-92-0Relevant articles and documents
Antivlral protease inhibitors
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Page/Page column 16-17, (2010/02/10)
Compounds of the formula (I) wherein: X and Y are hydroxy or H. A' and A'' are terminal amine functions such valinamide or indanolamine. Z' and Z'' along with the adjacent ()n groups are independently alkylaryl have utility as HIV aspartyl protease inhibi
Synthesis of novel, potent, diol-based HIV-1 protease inhibitors via intermolecular pinacol homocoupling of (2S)-2-benzyloxymethyl-4-phenylbutanal
Mühlman,Lindberg,Classon,Unge,Hallberg,Samuelsson
, p. 3407 - 3416 (2007/10/03)
The synthesis of novel, potent, diol-based HIV-1 protease inhibitors, having phenethyl groups (-CH2CH2Ph) in P1/P1′ position is described. An intermolecular pinacol homocoupling of (2S)-2-benzyloxymethyl-4-phenylbutanal 16 was the ke