373-31-9Relevant academic research and scientific papers
Silver-catalyzed radical fluorination of alkylboronates in aqueous solution
Li, Zhaodong,Wang, Zhentao,Zhu, Lin,Tan, Xinqiang,Li, Chaozhong
supporting information, p. 16439 - 16443 (2015/01/09)
We report herein an efficient and general method for the deboronofluorination of alkylboronates. Thus, with the catalysis of AgNO3, the reactions of various alkylboronic acids or their pinacol esters with Selectfluor reagent in acidic aqueous solution afforded the corresponding alkyl fluorides under mild conditions. A broad substrate scope and wide functional group compatibility were observed. A radical mechanism is proposed for this site-specific fluorination.
Approaches towards the synthesis of fluoro(cyclo)alkylamines
Windhorst,Bechger,Visser,Menge,Leurs,Timmerman,Herscheid
, p. 35 - 40 (2007/10/03)
The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.
