3731-52-0

Basic information

• Product Name: 3-(Aminomethyl)pyridine
• Synonyms: 3-(AMINOMETHYL)PYRIDINE;3AMPY;3-PYRIDINEMETHANAMINE;3-PYRIDYLMETHYLAMINE;3-PICOLYLAMINE;AKOS BBS-00003679;Picolamine;OMEGA-AMINO-B-PICOLINE
• CAS NO: 3731-52-0
• Molecular Formula: C₆H₈N₂
• Molecular Weight: 108.14
• EINECS: 223-091-0
• Product Categories: Nitrogen cyclic compounds;Pyridines derivates;Amines;Aromatics;Heterocycles;Miscellaneous Reagents;Building Blocks;C6;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines
• Mol File: 3731-52-0.mol
• Article Data: 50

Chemical Properties

• Melting Point: −21 °C(lit.)
• Boiling Point: 73-74 °C1 mm Hg(lit.)
• Flash Point: 213 °F
• Appearance: Clear colourless to slighly yellow liquid
• Density: 1.062 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0838mmHg at 25°C
• Refractive Index: n20/D 1.551(lit.)
• Storage Temp.: -20?C Freezer
• PKA: 8.34±0.29(Predicted)
• Water Solubility: FREELY SOLUBLE
• Sensitive: Air Sensitive
• BRN: 108056
• CAS DataBase Reference: 3-(Aminomethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Aminomethyl)pyridine(3731-52-0)
• EPA Substance Registry System: 3-(Aminomethyl)pyridine(3731-52-0)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-37-36/37/38
• Safety Statements: 26-36/37/39-45-25-36
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 3731-52-0(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS TO SLIGHLY YELLOW LIQUID

Uses

Different sources of media describe the Uses of 3731-52-0 differently. You can refer to the following data:
1. rubefacient
2. It finds its application as a rubefacient.

InChI:InChI=1/C6H8N2/c7-4-6-2-1-3-8-5-6/h1-3,5H,4,7H2/p+1

Synthetic route

pyridine-3-carbonitrile (100-54-9) → 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
With sodium tetrahydroborate In water; dimethyl sulfoxide at 60℃; for 6h; High pressure; Green chemistry;	99.9%
With palladium 10% on activated carbon; ammonia; hydrogen In methanol at 30℃; under 7500.75 Torr; for 4h; Reagent/catalyst; Temperature; Pressure; Autoclave;	93.44%
With hydrogen; silica gel; nickel In methanol; ammonia at 120℃; under 7600 Torr; for 6h;	86%

3-pyridinecarboxaldehyde (500-22-1) → 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
With ammonia; hydrogen In methanol at 30℃; for 20h; Autoclave;	97%
With N,N'-bis(salicylidene)-1,2-phenylene-diaminocobalt(II); ammonia; hydrogen In water at 120℃; for 24h; Autoclave;	84%
Multi-step reaction with 2 steps 1: water; potassium carbonate; hydroxylamine hydrochloride 2: ethanol; zinc; acetic acid View Scheme

3-hydroxymethylpyridin (100-55-0) → 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In tert-Amyl alcohol at 140℃; for 20h; Inert atmosphere; Cooling;	96%
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In tert-Amyl alcohol at 140℃; under 12001.2 Torr; for 20h; Inert atmosphere; Autoclave; chemoselective reaction;	96 %Chromat.

pyridine-3-carbonitrile (100-54-9) + ammoniacal methanol → 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
	85.6%
	84.2%

6-chloronicotinonitrile (33252-28-7) → 3-Aminomethylpyridine (3731-52-0) + 6-chloronicotinylaldehyde (23100-12-1) + bis(6-chloro-3-pyridylmethyl)amine + 5-(aminomethyl)-2-chloropyridine (97004-04-1)

Conditions	Yield
With ammonia; hydrogen; Sponge Ni In ethanol at 50℃; under 760 Torr; for 5h; Reduction;	A 3% B 5% C 8% D 75%
With ammonia; hydrogen; Sponge Ni In ethanol at 50℃; under 912 - 1064 Torr; for 9h; Product distribution; Further Variations:; Catalysts; Pressures; Temperatures; Reduction;	A 2% B 1% C 2% D 73%
With ammonia; hydrogen; Sponge Ni In ethanol at 50℃; under 912 - 1064 Torr; Reduction;	A 2% B 2% C 2% D 73%
With hydrogen; Raney Nickel R-100 In methanol; ammonium hydroxide at 25℃; under 760 Torr; for 9h; Product distribution; Further Variations:; Catalysts; Pressures; Solvents; Temperatures; Hydrogenation;	A 11% B 3% C 17% D 59%

nicotinaldehyde oxime (51892-16-1) → 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol for 0.5h; Ambient temperature;	74%
With ethanol; acetic acid; zinc

6-chloronicotinonitrile (33252-28-7) → 3-Aminomethylpyridine (3731-52-0) + bis(6-chloro-3-pyridylmethyl)amine + 5-(aminomethyl)-2-chloropyridine (97004-04-1)

Conditions	Yield
With ammonia; hydrogen; Sponge Ni In ethanol at 50℃; under 760 Torr; for 1.5h; Reduction;	A 17% B 3% C 62%

pyridine-3-carbonitrile (100-54-9) → 3-Aminomethylpyridine (3731-52-0) + bis(pyridin-3-ylmethyl)amine (1656-94-6)

Conditions	Yield
With 1,4-dioxane; nickel at 130℃; under 147102 Torr; Hydrogenation;
With ethanol; nickel at 130℃; under 147102 Torr; Hydrogenation;
With ammonia; nickel at 70 - 80℃; under 77228.3 Torr; Hydrogenation;

3-Methylpyridine (108-99-6) → pyridine-3-carbonitrile (100-54-9) + 3-Aminomethylpyridine (3731-52-0) + carbon dioxide (124-38-9) + nicotinamide (98-92-0)

Conditions	Yield
With ammonia; oxygen; vanadia at 375℃; Product distribution; other catalysts, effect of the presence of O2;

pyridine-3-carbonitrile (100-54-9) + chromium (II)-acetate + aq.-ethanolic KOH-solution + hydrogen → 3-Aminomethylpyridine (3731-52-0)

1,4-dioxane (123-91-1) + pyridine-3-carbonitrile (100-54-9) + Raney nickel → 3-Aminomethylpyridine (3731-52-0) + bis(pyridin-3-ylmethyl)amine (1656-94-6)

Conditions	Yield
at 130℃; under 147102 Torr; Hydrogenation;

pyridine-3-carbonitrile (100-54-9) + ethanol (64-17-5) + Raney nickel → 3-Aminomethylpyridine (3731-52-0) + bis(pyridin-3-ylmethyl)amine (1656-94-6)

Conditions	Yield
at 130℃; under 147102 Torr; Hydrogenation;

nicotinic acid (59-67-6) → 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonium acetate; acetic acid / Langsame Destillation des Reaktionsgemisches 2: Raney nickel; ethanol; dioxane / Hydrogenation View Scheme
Multi-step reaction with 2 steps 1: ammonium acetate; acetic acid / Langsame Destillation des Reaktionsgemisches 2: Raney nickel; ethanol / 130 °C / 147102 Torr / Hydrogenation View Scheme

1,3,5-tris(pyridin-3-ylmethyl)-1,3,5-triazine (261958-73-0) → 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
With hydrogenchloride In methanol; water

nicotinamide (98-92-0) → 3-hydroxymethylpyridin (100-55-0) + 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
With tris(2,4-pentanedionato)ruthenium(III); ytterbium(III) trifluoromethanesulfonate nonohydrate; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 150℃; under 3750.38 Torr; for 15h; Autoclave;	A n/a B 11 %Chromat.

2-(3-pyridinylmethyl)-1H-isoindole-1,3(2H)-dione (34403-38-8) → 3-Aminomethylpyridine (3731-52-0) + phthalyl alcohol (612-14-6)

Conditions	Yield
With [Ru(PtBuNNHtBu)H(CO)Cl]; potassium tert-butylate; hydrogen In tetrahydrofuran at 110℃; under 15001.5 Torr; for 24h; Autoclave;

pyridine-3-carbonitrile (100-54-9) → 3-Aminomethylpyridine (3731-52-0) + nicotinamide (98-92-0)

Conditions	Yield
With ammonium hydroxide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen at 100℃; under 20686.5 Torr; for 24h; Autoclave; Green chemistry; chemoselective reaction;

C18H20N2Si2 → 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
With water; sodium hydroxide In tetrahydrofuran; methanol at 20℃;

3-pyridinealdoxime (1193-92-6) → 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
With hydrogenchloride; zinc In ethanol; dichloromethane; water for 2h;

C6H8N2*H(1+) → 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
Multi-step reaction with 4 steps 1: water 2: oxygen 3: hydroxylamine; hydrogenchloride / water; ethanol; dichloromethane / 2 h / 20 °C 4: hydrogenchloride; zinc / water; ethanol; dichloromethane / 2 h View Scheme

C6H7NO*H4N(1+) → 3-Aminomethylpyridine (3731-52-0)

Conditions	Yield
Multi-step reaction with 3 steps 1: oxygen 2: hydroxylamine; hydrogenchloride / water; ethanol; dichloromethane / 2 h / 20 °C 3: hydrogenchloride; zinc / water; ethanol; dichloromethane / 2 h View Scheme

3-Aminomethylpyridine (3731-52-0) + di-tert-butyl dicarbonate (24424-99-5) → 3-methyl>pyridine (102297-41-6)

Conditions	Yield
In 1,4-dioxane for 3h; Ambient temperature;	100%
With glycerol at 20℃; for 0.0833333h; Green chemistry; chemoselective reaction;	96%
With sulfated tungstate 10 wt % In neat (no solvent) at 20℃; for 0.0833333h; chemoselective reaction;	95%

3-Aminomethylpyridine (3731-52-0) + acetic anhydride (108-24-7) → N-(pyridin-3-ylmethyl)acetamide (22977-34-0)

Conditions	Yield
In water at 10 - 25℃; for 18h;	100%
In tetrahydrofuran at 20℃; for 5h;	85%
With pyridine; dmap for 92h; Ambient temperature;	46%

3-Aminomethylpyridine (3731-52-0) + propynoic acid methyl ester (922-67-8) → (E)-3-[(Pyridin-3-ylmethyl)-amino]-acrylic acid methyl ester

Conditions	Yield
In tetrahydrofuran for 5h; Ambient temperature;	100%

3-Aminomethylpyridine (3731-52-0) + fenoxaprop-p-ethyl (66441-23-4, 71283-80-2) → (R)-2-(4-hydroxyphenoxy)propionic acid ethyl ester (71301-98-9) + (6-chloro-benzooxazol-2-yl)-pyridin-3-yl-amine

Conditions	Yield
at 20℃;	A n/a B 100%

3-Aminomethylpyridine (3731-52-0) + (2,2,5,7,8-pentamethylchroman-6-sulfonyl)isothiocyanate (773147-11-8) → C21H27N3O3S2 (1061736-60-4)

Conditions	Yield
In dichloromethane at 0℃; for 0.25h;	100%

3-Aminomethylpyridine (3731-52-0) + Benzophenone imine (1013-88-3) → N-(diphenylmethylene)-1-(pyridin-3-yl)methanamine (175441-83-5)

Conditions	Yield
at 50 - 60℃;	100%

3-Aminomethylpyridine (3731-52-0) + benzaldehyde (100-52-7) → (E)-N-phenylmethylene-1-(3-pyridyl)methanamine (1256973-71-3)

Conditions	Yield
In dichloromethane at 20℃; for 12h; Molecular sieve;	100%

3-Aminomethylpyridine (3731-52-0) + ethyl 2-(2-amino-4,6-dichloropyrimidin-5-yl)acetate (848694-76-8) → 2-amino-4-chloro-7-(pyridin-3-ylmethyl)-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one (1196886-72-2)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 120℃; for 12h; Inert atmosphere;	100%

3-Aminomethylpyridine (3731-52-0) + salicylaldehyde (90-02-8) → N-salicylidene-3-(aminomethyl)pyridine (58199-72-7)

Conditions	Yield
In benzene for 24h; Reflux;	99%
In benzene for 24h; Reflux;	99%
In ethanol at 98℃; for 1h;	92%

3-Aminomethylpyridine (3731-52-0) + 2,4 dichlorobenzoic acid (50-84-0) + potassium carbonate (584-08-7) → 4-Chloro-2-(pyridin-3-ylmethylamino)benzoic acid

Conditions	Yield
copper(I) bromide In N,N-dimethyl-formamide	99%

3-Aminomethylpyridine (3731-52-0) + C23H15NO8 → N-[4,8-etheno-8-(2-furyl)-1,3,5,7-tetraoxo-2,6-bis(3-pyridylmethyl)dodecahydropyrrolo[3,4-f]isoindol-4-yl]benzamide

Conditions	Yield
In water at 160℃; for 0.833333h; microwave irradiation;	99%

3-Aminomethylpyridine (3731-52-0) + 2-isopropyl-1-(prop-2-yn-1-yl)-1H-indazol-3(2H)-one (1309979-75-6) → 2-isopropyl-1-((1-(pyridin-3-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)-1H-indazol-3(2H)-one

Conditions	Yield
Stage #1: 3-Aminomethylpyridine With imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; potassium carbonate In methanol at 20℃; for 24h; Stage #2: 2-isopropyl-1-(prop-2-yn-1-yl)-1H-indazol-3(2H)-one With sodium L-ascorbate In methanol; water at 20℃; for 24h;	99%

3-Aminomethylpyridine (3731-52-0) + 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methylacrylic acid (1321992-09-9) → 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methyl-N-(pyridin-3-ylmethyl)acrylamide (1321992-40-8)

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetra fluoroborate; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 20℃; for 1h; Inert atmosphere;	99%

3-Aminomethylpyridine (3731-52-0) + Hexyl isocyanate (2525-62-4) → 1-hexyl-3-(pyridin-3-ylmethyl)urea (1231764-78-5)

Conditions	Yield
In dichloromethane at 0℃; Reflux;	99%

3-Aminomethylpyridine (3731-52-0) + 2E-3-((3S,4S,4aS,5S,6S,7R,8aR)-3,4,4a,5,6,7,8,8a-octahydro-6-(tertbutyldimethylsiloxy)-3,5,7-trimethylnaphthalen-4-yl)acrylic acid (1417091-40-7) → 2E-3-((3S,4S,4aS,5S,6S,7R,8aR)-3,4,4a,5,6,7,8,8a-octahydro-6-(tertbutyldimethylsiloxy)-3,5,7-trimethylnaphthalen-4-yl)-N-((pyridin-3-yl)methyl)acrylamide (1417091-43-0)

Conditions	Yield
Stage #1: 2E-3-((3S,4S,4aS,5S,6S,7R,8aR)-3,4,4a,5,6,7,8,8a-octahydro-6-(tertbutyldimethylsiloxy)-3,5,7-trimethylnaphthalen-4-yl)acrylic acid With dmap; 2-methyl-6-nitrobenzoic anhydride at 20℃; for 0.166667h; Inert atmosphere; Stage #2: 3-Aminomethylpyridine at 20℃; for 13h; Inert atmosphere;	99%

3-Aminomethylpyridine (3731-52-0) → 1-(pyridin-3-yl)-N-(pyridin-3-ylmethylene)methanamine (141136-36-9)

Conditions	Yield
With oxygen In acetonitrile at 80℃; under 2250.23 Torr; for 5h; Autoclave;	99%
With NC-800; air In water; dimethyl sulfoxide at 120℃; for 8h; Green chemistry;	93%
With N,N-diallyl-2,3,5,6-tetramethylpyrazine; oxygen In neat (no solvent) at 100℃; for 16h; Schlenk technique;	65%

3-Aminomethylpyridine (3731-52-0) + 3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride (129-64-6) → (1α,2α,6α,7α)-4-(pyridin-3-ylmethyl)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

Conditions	Yield
In toluene at 200℃; for 0.166667h;	99%

3-Aminomethylpyridine (3731-52-0) + dimethyl (1α,2α,6α,7α,8β,11β)-3,5-dioxo-4-oxatetracyclo[5.4.1.02,6.08,11]dodec-9-ene-9,10-dicarboxylate (856244-88-7) → dimethyl (1α,2α,6α,7α,8β,11β)-3,5-dioxo-4-(pyridin-3-ylmethyl)-4-azatetracyclo[5.4.1.02,6.08,11]dodec-9-ene-9,10-dicarboxylate

Conditions	Yield
at 170℃; for 0.0833333h;	99%

3-Aminomethylpyridine (3731-52-0) + phenylacetic acid (103-82-2) → 2-phenyl-N-((pyridin-3-yl)methyl)acetamide (349404-17-7)

Conditions	Yield
With Cp2Zr(OTf)2•THF In tetrahydrofuran at 70℃; for 48h; Sealed tube; Inert atmosphere;	99%
Stage #1: 3-Aminomethylpyridine; phenylacetic acid In methanol; water at 20℃; for 5h; Stage #2: With N-tosylimidazole In N,N-dimethyl-formamide at 100℃; for 1h; Stage #3: With triethylamine In N,N-dimethyl-formamide at 100℃;

3-Aminomethylpyridine (3731-52-0) + N,N-dimethyl-formamide (68-12-2, 33513-42-7) → N-(pyridine-2-yl)methylformamide (56625-04-8)

Conditions	Yield
Stage #1: N,N-dimethyl-formamide With bis(2-chlorophenyl)borinic acid; acetic acid at 65℃; for 0.25h; Inert atmosphere; Stage #2: 3-Aminomethylpyridine at 65℃; for 12h; Temperature; Inert atmosphere;	99%

3-Aminomethylpyridine (3731-52-0) + 3-O-acetylbetulinic acid chloride (59868-82-5) → (3β)-28-oxo-28-[(pyridin-3-ylmethyl)amino]lup-20(29)-en-3-yl acetate (917869-66-0)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h;	99%

3-Aminomethylpyridine (3731-52-0) + isobutyraldehyde (78-84-2) → isobutylidene-3-aminomethylpyridine

Conditions	Yield
In toluene	98.8%

3-Aminomethylpyridine (3731-52-0) + C6H9BF2O3 → C10H11BF2N2O2

Conditions	Yield
In acetonitrile at 25℃;	98%
In acetonitrile at 25℃; for 0.5h;	95%

3-Aminomethylpyridine (3731-52-0) + 4-fluorobenzoyl chloride (403-43-0) → 4-Fluoro-N-(pyridin-3-ylmethyl)benzamide (333433-98-0)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 1h;	98%

3-Aminomethylpyridine (3731-52-0) + 4-(t-butylmercapto)phenyl isocyanate (54528-31-3) → 1-(pyridin-3-ylmethyl)-3-(4-t-butylmercaptophenyl)-urea

Conditions	Yield
In benzene	98%
In benzene	98%

3-Aminomethylpyridine (3731-52-0) + benzaldehyde (100-52-7) → 3-(benzylaminomethyl)pyridine dihydrochloride

Conditions	Yield
With chloroform; 10% Pd/C; hydrogen In methanol at 20℃; under 760.051 Torr; for 3h; chemoselective reaction;	98%

3-Aminomethylpyridine (3731-52-0) → nicotinamide (98-92-0)

Conditions	Yield
With manganese(IV) oxide at 130℃; under 4560.31 Torr; for 3h;	98%
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); potassium tert-butylate In tert-butyl alcohol at 70℃; for 12h;	96%
With oxygen; potassium carbonate; copper(I) bromide In water; dimethyl sulfoxide at 140℃; under 760.051 Torr; for 6h;	90%

3-Aminomethylpyridine (3731-52-0) + (2E,4E)-5-((3S,4S,4aS,5S,6S,7R,8aR)-3,4,4a,5,6,7,8,8a-octahydro-6-(tert-butyldimethylsiloxy)-3,5,7-trimethylnaphthalen-4-yl)-2-ethylpenta-2,4-dienoic acid (1417091-59-8) → (2E,4E)-5-((3S,4S,4aS,5S,6S,7R,8aR)-3,4,4a,5,6,7,8,8a-octahydro-6-(tert-butyldimethylsiloxy)-3,5,7-trimethylnaphthalen-4-yl)-2-ethyl-N-((pyridin-3-yl)methyl)penta-2,4-dienamide (1417091-64-5)

Conditions	Yield
With dmap; 2-methyl-6-nitrobenzoic anhydride at 20℃; for 13h; Inert atmosphere;	98%

3-Aminomethylpyridine (3731-52-0) → (E)-1-(pyridin-3-yl)-N-(pyridin-3-ylmethylene)methanamine

Conditions	Yield
With C14H14N2(1+)*BF4(1-); oxygen In neat (no solvent) at 100℃; under 750.075 Torr; Schlenk technique;	98%
With dihydrogen peroxide In water at 100℃; for 16h; Sealed tube;	41 %Spectr.
With 1,5-diaminoanthraquinone; oxygen In [D3]acetonitrile at 30℃; for 24h; Solvent; Irradiation; Sealed tube;	77 %Spectr.

Upstream product

• 100-54-9 pyridine-3-carbonitrile 
• 98-92-0 nicotinamide 
• 1193-92-6 3-pyridinealdoxime 
• 34403-38-8 2-(3-pyridinylmethyl)-1H-isoindole-1,3(2H)-dione 
• 100-55-0 3-hydroxymethylpyridin 
• 261958-73-0 1,3,5-tris(pyridin-3-ylmethyl)-1,3,5-triazine 
• 500-22-1 3-pyridinecarboxaldehyde 
• 59-67-6 nicotinic acid 
• 64-17-5 ethanol 
• 123-91-1 1,4-dioxane 
• 33252-28-7 6-chloronicotinonitrile 
• 108-99-6 3-Methylpyridine 
• 51892-16-1 nicotinaldehyde oxime 

Downstream Products

• 297178-85-9 N-acetyl-sulfanilic acid-([3]pyridylmethyl-amide) 
• 100-55-0 3-hydroxymethylpyridin 
• 581-50-0 2,3'-bipyridine 
• 370-09-2 N-(3-pyridylmethyl)pyrrolidine 
• 58644-55-6 (3-Pyridylmethyl)isonitrile 
• 102297-41-6 3-<amino>methyl>pyridine 
• 22977-34-0 N-(pyridin-3-ylmethyl)acetamide 
• 94386-65-9 Pelrinone 
• 130169-01-6 {2-Methyl-6-oxo-4-[(pyridin-3-ylmethyl)-amino]-6H-pyrimidin-1-yl}-acetic acid methyl ester 
• 130740-22-6 5-Phenyl-1-pyridin-3-ylmethyl-1H-imidazole-4-carboxylic acid methyl ester 
• 136963-64-9 N-(2-chloroethoxysulfonyl), N'-(3-picolyl) uree 
• 136963-58-1 N-(2-chloroethoxysulfonyl), N'-(1-phenylethyl) uree 
• 58199-72-7 N-salicylidene-3-(aminomethyl)pyridine 
• 138305-15-4 4-Hydroxy-2-oxo-1-phenyl-N-(pyridin-3-ylmethyl)-1H-1,8-naphthyridine-3-carboxamide 

Relevant articles and documents

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PROCESS FOR REGENERATING A LIQUID ABSORBENT

The invention provides a process for regenerating a liquid absorbent, comprising: contacting the liquid absorbent with a hydrophobic medium, wherein the liquid absorbent comprises at least one amine of Formula (I) and degradation product thereof comprising at least one imine of Formula (II), wherein each Ar is independently an aromatic group and each R is independently selected from hydrogen, an organyl group and NH2; and selectively extracting the degradation product into or through the hydrophobic medium.

Ambient-Temperature Synthesis of Primary Amines via Reductive Amination of Carbonyl Compounds

Efficient synthesis of primary amines via low-temperature reductive amination of carbonyl compounds using NH3 and H2 as the nitrogen and hydrogen resources is highly desired and challenging in the chemistry community. Herein, we employed naturally occurring phytic acid as a renewable precursor to fabricate titanium phosphate (TiP)-supported Ru nanocatalysts with different reduction degrees of RuO2 (Ru/TiP-x, x represents the reduction temperature) by combining ball milling and molten-salt processes. Very interestingly, the obtained Ru/TiP-100 had good catalytic performance for the reductive amination of carbonyl compounds at ambient temperature, resulting from the synergistic cooperation of the support (TiP) and the Ru/RuO2 with a suitable proportion of Ru0 (52%). Various carbonyl compounds could be efficiently converted into the corresponding primary amines with high yields. More importantly, the conversion of other substrates with reducible groups could also be achieved at ambient temperature. Detailed investigations indicated that the partially reduced Ru and the support (TiP) were indispensable. The high activity and selectivity of Ru/TiP-100 catalyst originates from the relatively high acidity and the suitable electron density of metallic Ru0.