37318-49-3 Usage
Uses
Used in Biochemical Research:
EC 5.3.4.1 is used as a research tool for studying the functional role of triosephosphate isomerase in various metabolic pathways, such as glycolysis and gluconeogenesis. It helps researchers understand the enzyme's role in energy production and regulation.
Used in Drug Development:
Triosephosphate isomerase (TIM) is a potential target for the development of drugs to treat diseases related to glucose metabolism, such as diabetes and cancer. Inhibiting the enzyme's activity can disrupt the energy production in cancer cells, making it a promising target for cancer therapy.
Used in Enzyme Replacement Therapy:
In some genetic disorders, such as triosephosphate isomerase deficiency, patients may benefit from enzyme replacement therapy. EC 5.3.4.1 can be used as a therapeutic agent to replace the deficient enzyme, helping to alleviate symptoms and improve the patient's quality of life.
Used in Protein Engineering:
Triosephosphate isomerase (TIM) is a well-studied enzyme, and its structure and function have been extensively characterized. It serves as a model system for protein engineering and the development of novel biotechnological applications, such as the creation of enzymes with improved catalytic properties or altered substrate specificity.
Used in Metabolic Engineering:
EC 5.3.4.1 can be employed in metabolic engineering to optimize the production of specific metabolites or to redirect metabolic fluxes in microorganisms for the production of biofuels, biopolymers, or other valuable chemicals.
Used in Diagnostics:
Triosephosphate isomerase (TIM) can be used as a diagnostic marker for certain diseases, as its activity or expression levels may be altered in response to specific pathological conditions. Measuring the enzyme's activity or protein levels can help in the diagnosis and monitoring of these diseases.
Used in Education:
EC 5.3.4.1 serves as an important teaching tool in the fields of biochemistry, molecular biology, and cell biology. It helps students understand the principles of enzyme catalysis, metabolic regulation, and the role of enzymes in cellular processes.
Biochem/physiol Actions
Protein Disulfide Isomerase (PDI) is mainly located in the endoplasmic reticulum (ER), where it assists in protein-folding and thiol-disulfide exchanges. It aids protein refolding in vitro allowing recombinant proteins to achieve their native state.
Check Digit Verification of cas no
The CAS Registry Mumber 37318-49-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,3,1 and 8 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 37318-49:
(7*3)+(6*7)+(5*3)+(4*1)+(3*8)+(2*4)+(1*9)=123
123 % 10 = 3
So 37318-49-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H5Cl2NO5S/c8-4-2-5(9)6(16(13,14)15-10)1-3(4)7(11)12/h1-2H,10H2,(H,11,12)
