373361-41-2Relevant academic research and scientific papers
Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors
Lee, Jinho,Choi, Hwangeun,Kim, Kyoung-Hee,Jeong, Shinwu,Park, Jong-Wook,Baek, Chul-Su,Lee, Sei-Hee
, p. 2292 - 2295 (2008/09/20)
A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1λ6-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.
