373362-06-2

Upstream product

• 100-20-9 terephthaloyl chloride 
• 602308-96-3 3-{4-[(4-amino-1-methyl-1H-imidazole-2-carbonyl)-amino]-1-methyl-1H-pyrrol-2-yl}-acrylic acid ethyl ester 
• 1192-58-1 N-methylpyrrole aldehyde 
• 120095-64-9 2,2,2-trichloro-1-(1-methyl-4-nitro-1H-imidazol-2-yl)ethan-1-one 
• 373362-03-9 3-{1-methyl-4-[(1-methyl-4-nitro-1H-imidazole-2-carbonyl)-amino]-1H-pyrrol-2-yl}-acrylic acid ethyl ester 
• 373362-02-8 3-(1-methyl-4-nitro-1H-pyrrol-2-yl)-acrylic acid ethyl ester 
• 373362-29-9 3-(4-amino-1-methyl-1H-pyrrol-2-yl)-acrylic acid ethyl ester 
• 18711-27-8 1-methyl-4-nitro-1H-pyrrole-2-carboxaldehyde 

Downstream Products

• 373362-10-8 3-(4-{[4-(4-{2-[5-(2-carboxy-vinyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-benzoylamino)-1-methyl-1H-imidazole-2-carbonyl]-amino}-1-methyl-1H-pyrrol-2-yl)-acrylic acid 
• 373362-17-5 N,N'-bis-{2-[5-(3-imidazol-1-yl-3-oxo-propenyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-imidazol-4-yl}-terephthalamide 

Relevant academic research and scientific papers

Highly efficient sequence-specific DNA interstrand cross-linking by pyrrole/imidazole CPI conjugates

We have developed a novel type of DNA interstrand cross-linking agent by synthesizing dimers of a pyrrole (Py)/imidazole (Im)-diamide-CPI conjugate, ImPyLDu86 (1), connected using seven different linkers. The tetramethylene linker compound, 7b, efficientl