373380-88-2Relevant academic research and scientific papers
Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor
Juteau, Helene,Gareau, Yves,Labelle, Marc,Sturino, Claudio F.,Sawyer, Nicole,Tremblay, Nathalie,Lamontagne, Sonia,Carriere, Marie-Claude,Denis, Danielle,Metters, Kathleen M.
, p. 1977 - 1984 (2007/10/03)
Potent and selective antagonists of the human EP3 receptor have been identified. The structure-activity relationship of the chemical series was conducted and we found several analogues displaying sub-nanomolar Ki values at the EP3 receptor and micromolar activities at the EP1, EP2 and EP4 receptors. The effect of added human serum albumin (HSA) on the binding affinity at the EP3 receptor was also investigated.
