373384-98-6Relevant academic research and scientific papers
Effects of a 3-alkyl-, 4-hydroxy- and/or 8-aromatic-substituent on the phenylethanolamine N-methyltransferase inhibitor potency and α2-adrenoceptor affinity of 2,3,4,5-tetrahydro-1H-2-benzazepines
Grunewald, Gary L.,Dahanukar, Vilas H.,Criscione, Kevin R.
, p. 1957 - 1965 (2007/10/03)
2,3,4,5-Tetrahydro-1H-2-benzazepine (THBA; 1) is nearly 100-fold more selective an inhibitor of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) versus the α2-adrenoceptor than is 1,2,3,4-tetrahydroisoquinoline (THIQ; 2) (1: PNMT Ksu
