373388-56-8

Basic information

• Product Name: (S)-(+)-2-[1-(6-methoxy-2-naphthyl)ethyl]-6-(4-chlorobenzylidene)thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one
• CAS NO: 373388-56-8
• Molecular Weight: 447.945
• Mol File: 373388-56-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-(+)-2-[1-(6-methoxy-2-naphthyl)ethyl]-6-(4-chlorobenzylidene)thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2-[1-(6-methoxy-2-naphthyl)ethyl]-6-(4-chlorobenzylidene)thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one(373388-56-8)
• EPA Substance Registry System: (S)-(+)-2-[1-(6-methoxy-2-naphthyl)ethyl]-6-(4-chlorobenzylidene)thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one(373388-56-8)

Safety Data

• Hazardous Substances Data: 373388-56-8(Hazardous Substances Data)

Upstream product

• 373388-50-2 (+)-1-[2-(6-methoxy-2-naphthyl)propanoyl]thiosemicarbazide 
• 104400-30-8 (S)-2,5-dioxopyrrolidin-1-yl-2-(6-methoxynaphthalen-2-yl)propanoate 
• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 79-11-8 chloroacetic acid 
• 373388-51-3 (S)-(+)-3-[1-(6-methoxy-2-naphthyl)ethyl]-5-mercapto-1,2,4-triazole 

Relevant articles and documents

Synthesis, characterization and antiinflammatory-analgesic properties of 6-(alpha-amino-4-chlorobenzyl)thiazolo [3,2-b]-1,2,4-triazol-5-ols.

A series of 6-(alpha-amino-4-chlorobenzyl)-thiazolo[3,2-b]-1,2,4-triazol-5-ols (2a-j) were synthesized from 6-(4-chlorobenzylidene) thiazolo[3,2-b]-1,2,4-triazolo-5(6H)-one (2) by applying Michael addition reaction. All the compounds were characterized by their melting points, elementary analysis, IR and 1H-NMR spectra and screened for their anti-inflammatory and analgesic activities. Among the derivatives compound 2i bearing 4-(4-acetylphenyl)piperazine showed the highest and dose-dependent analgesic and anti-inflammatory activity without inducing any gastric lesion.