3736-81-0 Usage
Uses
Different sources of media describe the Uses of 3736-81-0 differently. You can refer to the following data:
1. selective agonist for delta-opioid receptor
2. Antidiarrhoeals / Antiprotozoles
3. Furamide is an ambecide, an anti-protozoal drug used in the treatment of amoebozoa infections.
Indications
Diloxanide furoate (Furamide) is an amebicide that is
effective against trophozoites in the intestinal tract. In
mild or asymptomatic infections, cures of 83 to 95%
have been achieved; in patients with dysentery, cure
rates may be less impressive. The drug is administered
only orally and is rapidly absorbed from the gastrointestinal
tract following hydrolysis of the ester group. It
is remarkably free of side effects, but occasionally flatulence,
abdominal distention, anorexia, nausea, vomiting,
diarrhea, pruritus, and urticaria occur. Diloxanide is excreted
in the urine, largely as the glucuronide. It is not
available in the United States.
Clinical Use
Diloxanide furoate (available from the Centers for Disease Control and Prevention [CDC]) is
prescribed for the treatment of asymptomatic amebiasis but is ineffective as a single agent for the
extraintestinal form of the disease. The drug is
administered orally and is hydrolyzed in the gut to give diloxanide, which is considered to be the
active drug. Diloxanide is the only form identified in the bloodstream. The drug is found in the
urine as the glucuronide.
Check Digit Verification of cas no
The CAS Registry Mumber 3736-81-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,3 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3736-81:
(6*3)+(5*7)+(4*3)+(3*6)+(2*8)+(1*1)=100
100 % 10 = 0
So 3736-81-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3
3736-81-0Relevant articles and documents
Redox-Neutral Selenium-Catalysed Isomerisation of para-Hydroxamic Acids into para-Aminophenols
Chuang, Hsiang-Yu,Schupp, Manuel,Meyrelles, Ricardo,Maryasin, Boris,Maulide, Nuno
, p. 13778 - 13782 (2021/03/31)
A selenium-catalysed para-hydroxylation of N-aryl-hydroxamic acids is reported. Mechanistically, the reaction comprises an N?O bond cleavage and consecutive selenium-induced [2,3]-rearrangement to deliver para-hydroxyaniline derivatives. The mechanism is studied through both 18O-crossover experiments as well as quantum chemical calculations. This redox-neutral transformation provides an unconventional synthetic approach to para-aminophenols.