373627-28-2

Basic information

• Product Name: 1H-Pyrazole-4-carbonyl chloride, 3-(4-chlorophenyl)-1-phenyl-
• CAS NO: 373627-28-2
• Molecular Formula: C16H10Cl2N2O
• Molecular Weight: 317.174
• Mol File: 373627-28-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carbonyl chloride, 3-(4-chlorophenyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carbonyl chloride, 3-(4-chlorophenyl)-1-phenyl-(373627-28-2)
• EPA Substance Registry System: 1H-Pyrazole-4-carbonyl chloride, 3-(4-chlorophenyl)-1-phenyl-(373627-28-2)

Safety Data

• Hazardous Substances Data: 373627-28-2(Hazardous Substances Data)

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 57845-08-6 p-chloroacetophenone phenylhydrazone 
• 99-91-2 para-chloroacetophenone 
• 36663-00-0 1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde 
• 372107-14-7 1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid 

Downstream Products

• 372490-45-4 3-(4-chloro-phenyl)-1-phenyl-1H-pyrazole-4-carboxylic acid hydrazide 
• 443912-33-2 3-(4-chloro-phenyl)-4-isocyanato-1-phenyl-1H-pyrazole 
• 376352-37-3 methyl 3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-carboxylate 

Relevant articles and documents

Synthesis, biological evaluation and molecular docking studies of pyrazole derivatives coupling with a thiourea moiety as novel CDKs inhibitors

It was discovered that a number of cyclin dependent kinase inhibitors containing the pyrazole core structure exhibited high inhibitory potency against broad-range CDKs and corresponding anti-proliferative activities. This information guided us to design and synthesize a series of 1,3-diphenyl-N- (phenylcarbamothioyl)-1H-pyrazole-4-carboxamide derivatives (5a-10d), and evaluate their biological activities as CDKs inhibitors. Among all the synthesized compounds, compound 10b inhibited CDK2 with an IC50 value of 25 nM, counteracting tumor cell proliferation of three cancer cell lines (H460, MCF-7, A549) in the micromolar range (from 0.75 μM to 4.21 μM), In addition, flow cytometry indicated that compound 10b could induce cycle G 0/G1 phase arrest in A549 cells with a dose dependent. Taken together, compound 10b could be selected for further preclinical evaluation.

4-Functionally substituted 3-heterylpyrazoles: III. 3-aryl(heteryl)pyrazole-4-carboxylic acids and their derivatives

3-Aryl(heteryl)-4-formylpyrazoles were cleanly oxidized by potassium permanganate in water-pyridine medium to afford in high yield 3-aryl(heteryl)pyrazole-4-carboxylic acids, that were further converted into the corresponding chlorides and amides.