373645-65-9

Upstream product

• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 152480-59-6 para-Methoxybenzyltrichloroacetimidate 
• 373645-64-8 2,6-dimethylphenyl (4Z,6S,7R,8S)-9-(p-methoxybenzyloxy)-7-hydroxy-4,6,8-trimethyl-4-nonenoate 
• 373645-87-5 (Z)-(6S,7R,8S)-7-Hydroxy-9-(4-methoxy-benzyloxy)-4,6,8-trimethyl-non-4-enoic acid 
• 261968-07-4 (Z)-(6S,7R,8S)-7-(tert-butyldimethylsilanyloxy)-9-(4-methoxybenzyloxy)-4,6,8-trimethylnon-4-enoic acid 2,6-dimethylphenyl ester 
• 261968-18-7 (2S,4R,5R,6S)-2-benzoyloxy-7-(t-butyldimethylsilyloxy)-5-(p-methoxybenzyloxy)-4,6-dimethylheptan-3-one 
• 373645-85-3 (Z)-(6S,7R,8S)-7-(tert-butyldimethylsilanyloxy)-9-(4-methoxybenzyloxy)-4,6,8-trimethylnon-4-enoic acid 
• 261968-16-5 (Z)-(6S,7R,8S)-7-(tert-butyldimethylsilanyloxy)-9-(4-methoxybenzyloxy)-4,6,8-trimethylnon-4-enoic acid methyl ester 
• 261968-14-3 6-[1-(p-methoxybenzyloxy)-2-propyl]-2-(phenylseleno)methyl-4-isopropenyl-[1,3]-dioxane 
• 261968-19-8 [2S,4S,5R,6S]-7-(t-butyldimethylsilyloxy)-5-(p-methoxybenzyloxy)-4,6-dimethylheptan-2,3-diol 
• 261968-13-2 Propionic acid (1R,2R,3S,4S)-3-hydroxy-1-isopropenyl-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pentyl ester 
• 261968-17-6 (2S,4R,5R,6S)-7-(tert-butyldimethylsilyloxy)-5-hydroxy-4,6-dimethyl-3-oxoheptan-2-yl benzoate 
• 373645-84-2 methyl (4Z,6S,7R,8S)-9-(p-methoxybenzyloxy)-7-hydroxy-4,6,8-trimethyl-4-nonenoate 
• 373645-63-7 1-(p-methoxybenzyloxy)-3,5-dihydroxy-2,4,6-trimethyl-6-heptene 

Downstream Products

• 373645-66-0 (3Z,5S,6S,7R,8S,9R,11Z,13S,14R,15S)-14-(t-butyldimethylsilyloxy)-6,16-bis(p-methoxybenzyloxy)-9-[(2,4,6-trimethylphenyl)sulfoxymethyl]-5,7,11,13,15-pentamethyl-hexadeca-1,3,11-trien-8-ol 
• 373645-83-1 tert-Butyl-{(Z)-(1R,2S)-5-{(2R,3R)-2-[(Z)-(1R,2S,3S)-2-(4-methoxy-benzyloxy)-1,3-dimethyl-hepta-4,6-dienyl]-oxetan-3-yl}-1-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,4-dimethyl-pent-3-enyloxy}-dimethyl-silane 
• 256920-81-7 1-[(5Z,13Z)-(2S,3R,4S,8S,9R,10R,11S,12S)-11-(4-methoxybenzoxy)-3,9-bis(tert-butyldimethylsilanyloxy)-2,4,6,8,10,12-hexamethylhexadeca-5,13,15-trienyloxymethyl]-4-methoxybenzene 
• 261968-22-3 (3Z,5S,6S,7S,8R,9S,11Z,13S,14R,15S)-14-(t-butyldimethylsilyloxy)-6,16-bis-(p-methoxybenzyloxy)-5,7,9,11,13,15-hexamethyl-hexadeca-1,3,11-trien-8-ol 

Relevant academic research and scientific papers

A second-generation total synthesis of (+)-discodermolide: The development of a practical route using solely substrate-based stereocontrol

(Chemical Equation Presented). A novel total synthesis of the complex polyketide (+)-discodermolide, a promising anticancer agent of sponge origin, has been completed in 7.8% overall yield over 24 linear steps, with 35 steps altogether. This second-genera

A practical synthesis of (+)-discodermolide and analogues: Fragment union by complex aldol reactions

A practical stereocontrolled synthesis of (+)-discodermolide (1) has been completed in 10.3% overall yield (23 steps longest linear sequence). The absolute stereochemistry of the C1-C6 (7), C9-C16 (8), and Csub

Total synthesis of the antimicrotubule agent (+)-discodermolide using boron-mediated aldol reactions of chiral ketones

With a similar mechanism of action to taxol, the title compound 1 is a particularly promising candidate for development in cancer chemotherapy. This efficient synthesis, based on stereocontrolled aldol reactions, should help to overcome the scarce natural