373791-74-3

Upstream product

• 269055-72-3 4-[(5-bromo-4-chloro-2-pyrimidinyl)amino]benzonitrile 
• 269055-04-1 4-[[5-bromo-4-(4-cyano-2,6-dimethylphenoxy)-2-pyrimidinyl]-amino]benzonitrile 
• 3188-13-4 ethyl chloromethyl ether 
• 244768-32-9 4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile 

Relevant academic research and scientific papers

PRODRUGS OF HIV REPLICATION INHIBITING PYRIMIDINES

The present invention concerns compounds of formula (A1)(A2)N—R1 (I), the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 is substituted C1-6alkyl; —S(═O)—R8; —S(═O)2—R8; C7-12alkylcarbonyl; optionally substituted C1-6alkyloxycarbonylC1-6alkylcarbonyl; with R8 being C1-6alkyl, aryl1 or Het1; (A1)(A2)N— is the covalently bonded form of the corresponding intermediate of formula (A1)(A2)N—H, which is a HIV replication inhibiting pyrimidine of formula