37390-66-2 Usage
Uses
Used in Biochemical Research:
2,6-Dichloropurine-2'-deoxyriboside is used as a research tool for studying the structure and function of DNA and RNA molecules. Its chemically modified structure allows researchers to investigate the effects of such modifications on the stability, folding, and interactions of nucleic acids.
Used in Drug Development:
In the pharmaceutical industry, 2,6-Dichloropurine-2'-deoxyriboside may be used as a lead compound for the development of new drugs targeting various diseases. Its unique structure could potentially be exploited to design molecules with specific binding affinities or activities against target proteins or enzymes.
Used in Diagnostic Applications:
2,6-Dichloropurine-2'-deoxyriboside could be employed in the development of diagnostic tools and assays, such as fluorescent probes or hybridization agents, for detecting specific DNA or RNA sequences. Its chemical modifications may enhance the sensitivity or specificity of these diagnostic methods.
Used in Chemical Synthesis:
In the field of organic chemistry, 2,6-Dichloropurine-2'-deoxyriboside may serve as a starting material or intermediate for the synthesis of other nucleoside analogs or related compounds with potential applications in medicine, biotechnology, or materials science.
Used in Environmental Applications:
Although not explicitly mentioned in the provided materials, 2,6-Dichloropurine-2'-deoxyriboside could potentially be used in environmental applications, such as the development of biosensors for detecting pollutants or monitoring water quality, due to its unique chemical properties and interactions with nucleic acids.
Check Digit Verification of cas no
The CAS Registry Mumber 37390-66-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,3,9 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 37390-66:
(7*3)+(6*7)+(5*3)+(4*9)+(3*0)+(2*6)+(1*6)=132
132 % 10 = 2
So 37390-66-2 is a valid CAS Registry Number.
37390-66-2Relevant academic research and scientific papers
Efficient biocatalytic synthesis of dihalogenated purine nucleoside analogues applying thermodynamic calculations
Giessmann, Robert T.,Kaspar, Felix,Klare, Hendrik F. T.,Kurreck, Jens,Neubauer, Peter,Paulick, Katharina,R?hrs, Viola,Wagner, Anke,Westarp, Sarah,Yehia, Heba
, (2020/02/28)
The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in transglycosylation reactions using uridine or thymidine as sugar donors. Prior to the enzymatic process, ideal maximum product yields were calculated after the determination of equilibrium constants through monitoring the equilibrium conversion in analytical-scale reactions. Equilibrium constants for dihalogenated nucleosides were comparable to known purine nucleosides, ranging between 0.071 and 0.081. To achieve 90% product yield in the enzymatic process, an approximately five-fold excess of sugar donor was needed. Nucleoside analogues were purified by semi-preparative HPLC, and yields of purified product were approximately 50% for all target compounds. To evaluate the impact of halogen atoms in positions 2 and 6 on the antiproliferative activity in leukemic cell lines, the cytotoxic potential of dihalogenated nucleoside analogues was studied in the leukemic cell line HL-60. Interestingly, the inhibition of HL-60 cells with dihalogenated nucleoside analogues was substantially lower than with monohalogenated cladribine, which is known to show high antiproliferative activity. Taken together, we demonstrate that thermodynamic calculations and small-scale experiments can be used to produce nucleoside analogues with high yields and purity on larger scales. The procedure can be used for the generation of new libraries of nucleoside analogues for screening experiments or to replace the chemical synthesis routes of marketed nucleoside drugs by enzymatic processes.
