374-99-2

Basic information

• Product Name: 2,2,3,3,4,4,4-HEPTAFLUOROBUTYLAMINE
• Synonyms: 2,2,3,3,4,4,4-heptafluoro-butylamin;Butylamine, 2,2,3,3,4,4,4-heptafluoro-;Heptafluorobutylamine;RARECHEM AL BW 0454;2,2,3,3,4,4,4-Heptafluorobutylamine,min.97%;1H,1H-Heptafluorobutylamine 97%;1H,1H-Heptafluorobutylamine97%;2,2,3,3,4,4,4-HEPTAFLUOROBUTYLAMINE, MIN. 97%
• CAS NO: 374-99-2
• Molecular Formula: C₄H₄F₇N
• Molecular Weight: 199.07
• EINECS: 206-780-0
• Product Categories: organofluorine compounds;Amines;Building Blocks;C2 to C5;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 374-99-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 70-71 °C
• Flash Point: 70-71°C
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.493
• Vapor Pressure: 153mmHg at 25°C
• Refractive Index: 1.296-1.298
• PKA: 5.89±0.30(Predicted)
• Water Solubility: Soluble in water.
• BRN: 1761906
• CAS DataBase Reference: 2,2,3,3,4,4,4-HEPTAFLUOROBUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,3,3,4,4,4-HEPTAFLUOROBUTYLAMINE(374-99-2)
• EPA Substance Registry System: 2,2,3,3,4,4,4-HEPTAFLUOROBUTYLAMINE(374-99-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 45-36/37/39-26
• RIDADR: 2735
• WGK Germany: 3
• RTECS: EO5190000
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 374-99-2(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

2,2,3,3,4,4,4-Heptafluorobutylamine is used as pharmaceutical intermediates

InChI:InChI=1/C4H4F7N/c5-2(6,1-12)3(7,8)4(9,10)11/h1,12H2/p+1

Upstream product

• 662-50-0 heptafluorobutyramide 

Downstream Products

• 377-00-4 1.1-Dihydro-perfluor-butyl-isocyanat 
• 1422-65-7 N-(1H,1H-heptafluoro-butyl)-acrylamide 
• 1239327-74-2 2,6-dibromo-N,N'-bis(1H,1H-perfluorobutyl)naphthalene[1,8:4,5]bis(dicarboximide) 
• 1346560-75-5 C₁₈H₄Br₂F₁₄N₂O₄ 
• 1185014-51-0 N₄-(2,2,3,3,4,4,4-heptafluoro-butyl)-N₂-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-6-methyl-pyrimidine-2,4-diamine 
• 374-98-1 2,2,3,3,4,4,4-heptafluoro-1-iodobutane 

Relevant articles and documents

Biomimetic reductive amination under the continuous-flow reaction conditions

This study present a full account of continuous-flow reaction conditions for biomimetic reductive amination of fluorinated carbonyl compounds to corresponding amines and amino acids of biomedical importance. We demonstrate that simple silica-adsorbed DBU can be used as efficient catalysts for on-column 1,3-proton shift reaction, a key transformation in the biomimetic reductive amination process. This new on-column process features operationally convenient conditions, higher chemical yields, enantioselectivity and purity of the corresponding products as compared with traditional in-flask reactions. Moreover the removal of base-catalyst, the most delicate problem of the in-flask reactions, is not an issue in the on-column process, as the silica-adsorbed DBU or polymer-bound guanidine remains on the column and can be reused. This feature renders the overall process substantially more economical and synthetically efficient, in particular, for large-scale synthesis of the corresponding fluorinated amines and amino acids target.