374067-96-6

Basic information

• Product Name: 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide
• Synonyms: 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide
• CAS NO: 374067-96-6
• Molecular Formula: C₁₀H₁₅NO₃S
• Molecular Weight: 229.3
• Product Categories: Chemical Amines;Amines;Aromatics;Sulfur & Selenium Compounds;Amines, Aromatics, Sulfur & Selenium Compounds
• Mol File: 374067-96-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 100-102°C
• Boiling Point: 398.906°C at 760 mmHg
• Flash Point: 195.052°C
• Appearance: /
• Density: 1.256g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: Refrigerator
• Solubility: DMSO, Ethyl Acetate, Methanol
• CAS DataBase Reference: 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide(374067-96-6)
• EPA Substance Registry System: 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide(374067-96-6)

Safety Data

• Hazardous Substances Data: 374067-96-6(Hazardous Substances Data)

Usage

Chemical Properties

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Uses

4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide (cas# 374067-96-6) is a compound useful in organic synthesis.

InChI:InChI=1/C10H15NO3S/c1-10(2,7-12)8-3-5-9(6-4-8)15(11,13)14/h3-6,12H,7H2,1-2H3,(H2,11,13,14)

Upstream product

• 57625-74-8 methyl 2-methyl-2-phenylpropionate 
• 321565-78-0 ethyl 2-(4-chlorosulfonylphenyl)-2-methylpropionate 
• 374067-94-4 ethyl 2-methyl-2-(4-sulfamoylphenyl)propionate 
• 2901-13-5 ethyl 2-methyl-2-phenylpropionate 
• 374067-95-5 2-methyl-2-(4-sulfamoylphenyl)propionic acid 

Downstream Products

• 245118-94-9 N-(6-chloro-5-(4-methylphenyl)-4-pyrimidinyl)-4-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamide 
• 169677-18-3 C₂₃H₂₇N₃O₅S 
• 253688-62-9 Ro 64-1056 
• 374068-00-5 2-(4-(N-(5-acetoxymethyl)phenyl-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N-acetylsulfamoyl)phenyl)-2-methylpropyl acetate 
• 245118-91-6 N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)-4-(1,1-dimethyl-2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzenesulfonamide 
• 374067-99-9 2-(4-(N-acetyl-N-(5-((4-bromomethyl)phenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate 
• 374067-98-8 2-(4-(N-acetyl-N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate 
• 245118-90-5 4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-N-[6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-benzenesulfonamide 
• 169679-53-2 N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-5-(4-methylphenyl)-4-pyrimidinyl]-4-(2-hydroxy-1,1-dimethylethyl)-benzenesulfonamide 
• 245118-89-2 N-(6-chloro-5-(4-methylphenyl)-4-pyrimidinyl)-4-(1,1-dimethyl-2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzenesulfonamide 

Relevant articles and documents

Chemical synthesis method of bosentan metabolite

The invention discloses a chemical synthesis method of bosentan metabolite. According to the method disclosed by the invention, the bosentan metabolite is obtained from 2, 2-dimethyl methyl phenylacetate through six-step reaction. The whole preparation method is high in operability, high in preparation efficiency and low in production cost, and industrial mass production can be achieved. The bosentan metabolite prepared by the invention is higher in bioavailability, can directly play a role in resisting hypertension, and is lower in adverse reaction.