374107-88-7Relevant academic research and scientific papers
LOW-SWELLING HYDROGEL SEALANTS FOR WOUND REPAIR
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Page/Page column 212-213, (2010/11/25)
One aspect of the present invention relates to a sealant comprising dendrimeric macromolecules that form a hydrogel. In certain instances, the sealants of the invention comprise a hydrogel that swells less than about 400 wt% upon hydration. In certain instances, the sealants of the present invention further comprise a pharmaceutical agent, such as an antibiotic, antimicrobial agent, or antiinflammatory agent. The sealants of the present invention may be used to treat a wound on a patient that is topical or in vivo. In addition, the sealants of the present invention can act as a barrier to bacteria and other organisms. Another aspect of the present invention relates to a method of sealing a wound on a patient comprising the steps of applying an effective amount of a dendrimeric compound to a wound on a patient and treating the dendrimeric compound with a polymerization agent. Another aspect of the present invention relates to a method of sealing a wound on a patient comprising the steps of treating a dendrimeric compound with a polymerization agent to form a repair agent, and applying the repair agent to a wound on a patient. Another aspect of the present invention relates to a kit for sealing a wound comprising a polymerizable dendrimeric compound that forms a hydrogel and a system for delivering the polymerizable dendrimeric compound to a wound on a patient.
