374119-33-2Relevant academic research and scientific papers
N-Arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B
Greenspan, Paul D.,Clark, Kirk L.,Cowen, Scott D.,McQuire, Leslie W.,Tommasi, Ruben A.,Farley, David L.,Quadros, Elizabeth,Coppa, David E.,Du, Zengming,Fang, Zheng,Zhou, Huanghai,Doughty, John,Toscano, Karen T.,Wigg, Andrew M.,Zhou, Siyuan
, p. 4121 - 4124 (2003)
To improve the pharmacokinetics of a previously reported series of dipeptidyl nitrile cathepsin B inhibitors, the P2-P3 amide group was replaced with an arylamine. Further optimization of this template resulted in highly potent and s
2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-YL-PIPERIDINES USED AS CGRP ANTAGONISTS
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Page/Page column 78-79, (2010/11/24)
The invention relates to novel CGRP antagonists of general formula (I), in which B, R1 and R2 are defined as cited in claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts, in addition to the hydrates of their salts, in particular their physiologically compatible salts, with inorganic or organic acids or bases. The invention also relates to medicaments containing said compounds, to their use and to a method for their production.
SELECTED CGRP ANTAGONISTS, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS
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Page/Page column 247, (2008/06/13)
The invention relates to CGRP antagonists of general formula (I), in which A, X, D, E, G, M, Q and R1 to R3 are defined as in Claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and their salts as well as the hydrates of the salts, particularly their physiologically compatible salts having inorganic or organic acids, to medicaments containing these compounds, to their use, and to methods for the production thereof.
N-substituted peptidyl nitriles as cysteine cathepsin inhibitors
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, (2008/06/13)
Compounds of the formula (I), wherein R1 is aryl or biaryl; R2 is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C2-C7/sub
