3743-29-1

Basic information

• Product Name: N-(m-hydroxyphenyl)-p-toluenesulphonamide
• Synonyms: Einecs 223-135-9;N-(m-hydroxyphenyl)-p-toluenesulphonamide;N-(3-Hydroxyphenyl)-4-methylbenzenesulfonamide;N-(3-Hydroxyphenyl)-p-toluenesulfonamide
• CAS NO: 3743-29-1
• Molecular Formula: C₁₃H₁₃NO₃S
• Molecular Weight: 263.31222
• EINECS: 223-135-9
• Product Categories: Aromatic Building Blocks
• Mol File: 3743-29-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 158 °C
• Boiling Point: 446.9°Cat760mmHg
• Flash Point: 224°C
• Appearance: /
• Density: 1.362g/cm³
• Storage Temp.: 2-8°C
• PKA: 8.06±0.10(Predicted)
• CAS DataBase Reference: N-(m-hydroxyphenyl)-p-toluenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(m-hydroxyphenyl)-p-toluenesulphonamide(3743-29-1)
• EPA Substance Registry System: N-(m-hydroxyphenyl)-p-toluenesulphonamide(3743-29-1)

Safety Data

• Hazardous Substances Data: 3743-29-1(Hazardous Substances Data)

Usage

General Description

N-(m-hydroxyphenyl)-p-toluenesulphonamide, also known as p-aminosalicylamide, is a chemical compound that has been used as a medication to treat tuberculosis. It works by inhibiting the synthesis of certain components of the bacterial cell wall, leading to the disruption of bacterial growth and replication. N-(m-hydroxyphenyl)-p-toluenesulphonamide has also been studied for its potential use in the treatment of certain types of cancer, as well as in the development of new antibiotic agents. Its chemical structure and functional groups make it a promising candidate for further research and development in the field of medicinal chemistry.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 591-27-5 m-Hydroxyaniline 
• 64-17-5 ethanol 

Downstream Products

• 1372874-82-2 C₃₄H₄₉NO₇Si 
• 1372874-81-1 C₂₈H₃₃NO₄ 
• 1372874-79-7 C₁₉H₁₉NO₅S 
• 1346523-56-5 7-[ethyl-(4-methanesulfonylphenyl)amino]-4-methylcoumarin 
• 333383-93-0 N-tosyl 7-hydroxyhydroquinoline 
• 578-67-6 quinolin-5-ol 
• 580-20-1 quinolin-7-ol 
• 925213-66-7 N-(3-{[4-(ethylamino)-5-nitro-2-pyridinyl]oxy}phenyl)-4-methylbenzenesulfonamide 
• 333383-80-5 3-(N-3-hydroxyphenyl-N-p-tosylpropionaldehyde) 
• 70-55-3 toluene-4-sulfonamide 
• 38920-02-4 C₃₄H₂₇N₃O₇S₂ 
• 38912-94-6 N-[3-(1-Amino-4-hydroxy-9,10-dioxo-9,10-dihydro-anthracen-2-yloxy)-phenyl]-4-methyl-benzenesulfonamide 
• 101973-09-5 7-[N-(p-toluenesulfonyl)amino]-4-methylcoumarin 
• 1365715-95-2 C₁₉H₁₈BrNO₄S 

Relevant articles and documents

N-(3-Hydroxyphenyl)-p-toluenesulfonamide

In the title compound, C13H13NO3S, the dihedral angle between the toluene and phenol moieties is 69.48 (5)°. The molecules form columns linked by N-H...O and O-H...O hydrogen bonds.

Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists

We describe the discovery of a series of arylsulfonyl 3-(pyridin-2-yloxy) anilines as GPR119 agonists derived from compound 1. Replacement of the three methyl groups in 1 with metabolically stable moieties led to the identification of compound 34, a potent and efficacious GPR119 agonist with improved pharmacokinetic (PK) properties.

7-Amino coumarin based fluorescent phototriggers coupled with nano/bio-conjugated bonds: Synthesis, labeling and photorelease

By several synthetic pathways, we designed and synthesized a new series of unsymmetrical substituted 7-amino coumarin-based phototriggers with various nano/bio-conjugated bonds. The photophysical properties of most of the substituted coumarin-based phototriggers, except for compound P9 with maleimide group, showed no significant change compared with that of 7-(diethylamino)-4- (hydroxylmethyl) coumarin (DEACM-OH, the reported symmetric substituted 7-amine coumarin based phototrigger). Four compounds (P2, P4, P9, 14) were successfully conjugated with typical carriers such as mesoporous silica nanoparticles, biocompatible polymer PEG and common protein BSA, respectively. The efficient photorelease of ibuprofen (IBU) in the model cargo delivery system of MD4 confirmed that our designed phototriggers could serve well as a photo-cage for bioactive molecules and the release can be regulated precisely by manipulating the external irradiation conditions. All the results hinted at the superiority of using these coumarin functional compounds for photo-regulated release in biotechnology and biomedical areas. The Royal Society of Chemistry 2012.