37436-25-2

Usage

Uses

Used in Pharmaceutical Industry:
6-Ethyl-2-tetralone is used as a precursor in the production of pharmaceuticals for its ability to be synthesized into various biologically active compounds, contributing to the development of new medications.
Used in Fragrance Industry:
It is utilized as a key intermediate in the creation of fragrances, capitalizing on its sweet, floral scent to enhance the olfactory profiles of various perfumes and scented products.
Used in Organic Synthesis:
6-Ethyl-2-tetralone is employed as a starting material in the preparation of other organic compounds, such as alkaloids and steroids, due to its versatile reactivity and functional groups, which make it an essential building block in organic chemistry.

Upstream product

• 21388-17-0 2-methoxy-6-ethylnaphthalene 
• 4133-35-1 6-bromo-2-tetralone 
• 74-96-4 ethyl bromide 
• 3900-45-6 6-methoxy-2-acetylnaphthalene 

Relevant academic research and scientific papers

Synthesis method of Alectinib

The invention discloses a synthesis method of Alectinib. The method comprises the following steps: carrying out a borating reaction between 6-bromo-3,4-dihydro-2-naphthalenone and n-butyl lithium and then an organic boron reagent; carrying out a catalytic coupling reaction between the obtained 3,4,-dihydro-2-naphthalenone-6-boric acid and bromoethane; carrying out a dimethylation reaction between the obtained 6-ethyl-3,4-dihydro-2-naphthalenone and iodomethane; carrying out a bromination reaction between the obtained 1,1-dimethyl-6-ethyl-3,4-dihydro-2-naphthalenone and a bromination reagent; carrying out a substitution reaction between the obtained 1,1-dimethyl-6-ethyl-7-bromo-3,4-dihydro-2-naphthalenone and 4-(4-piperidyl)morpholine; carrying out a cyclization reaction between the obtained 1,1-dimethyl-6-ethyl-7-[4-(morpholine-4-yl)piperidine-1-yl]-3,4-dihydro-2-naphthalenone and 3-cyanophenylhydrazine; and carrying out an oxidation reaction between the obtained 9-ethyl-6,6-dimethyl-8-[4-(morpholine-4-yl)piperidine-1-yl]-6,11-dihydro-5H-benzo[b]carbazole-3-formonitrile and dichlorodicyanobenzoquinone to obtain a finished product of Alectinib. The synthesis method has the advantages of relatively short route, simplified operation and relatively low cost and is a green and environment-friendly method suitable for industrial production.