374540-12-2Relevant academic research and scientific papers
One-pot three steps cascade synthesis of novel isoandrographolide analogues and their cytotoxic activity
Kasemsuk, Teerapich,Piyachaturawat, Pawinee,Bunthawong, Rada,Sirion, Uthaiwan,Suksen, Kanoknetr,Suksamrarn, Apichart,Saeeng, Rungnapha
, p. 952 - 963 (2017/07/28)
An efficient one-pot synthesis of novel andrographolide analogues is reported from a naturally occurring and abundant andrographolide isolated from aerial parts of Andrographis paniculata. Reactions in the one-pot proceed through a cascade epoxide ring op
New substituted C-19-andrographolide analogues with potent cytotoxic activities
Sirion, Uthaiwan,Kasemsook, Sakkasem,Suksen, Kanoknetr,Piyachaturawat, Pawinee,Suksamrarn, Apichart,Saeeng, Rungnapha
supporting information; experimental part, p. 49 - 52 (2012/02/16)
Andrographolide, the major diterpenoid lactone from Andrographis paniculata, is toxic against cancer cells. In the present study, we investigated the structure-activity relationships (SARs) of 19 andrographolide analogues which were synthesized by modific
