374590-18-8

Basic information

• Product Name: (2S,5S)-N-(4-benzyloxybutyryl)-2,5-bis(methoxymethoxymethyl)pyrrolidine
• Synonyms: (2S,5S)-N-(4-benzyloxybutyryl)-2,5-bis(methoxymethoxymethyl)pyrrolidine
• CAS NO: 374590-18-8
• Molecular Weight: 395.496
• Mol File: 374590-18-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,5S)-N-(4-benzyloxybutyryl)-2,5-bis(methoxymethoxymethyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-N-(4-benzyloxybutyryl)-2,5-bis(methoxymethoxymethyl)pyrrolidine(374590-18-8)
• EPA Substance Registry System: (2S,5S)-N-(4-benzyloxybutyryl)-2,5-bis(methoxymethoxymethyl)pyrrolidine(374590-18-8)

Safety Data

• Hazardous Substances Data: 374590-18-8(Hazardous Substances Data)

Upstream product

• 10385-30-5 4-(benzyloxy)butanoic acid 
• 93621-95-5 (2S,5S)-bis(methoxymethoxymethyl)pyrrolidine 

Downstream Products

• 374590-19-9 (2S,4S)-2-(2-Benzyloxy-ethyl)-1-((2S,5S)-2,5-bis-methoxymethoxymethyl-pyrrolidin-1-yl)-4-phenyl-hept-6-ene-1,3-dione 

Relevant articles and documents

Synthetic studies towards the octahydro-1H-benzo[f]pyrrolo[3,2,1-ij]quinolines: Enantioselective synthesis of (2R,3S)-2-[(1S)-3-(benzyloxy)-1-(tert-butyldimethyl-silyloxymethyl) propyl]-3-phenylhexahydropyridine

(2R,3S)-2-[(1S)-3-(Benzyloxy)-1-(tert-butyldimethylsilyloxymethyl)propyl]-3- phenylhexahydropyridine - a key synthetic intermediate for the preparation of (6aS,11bS,11cS)-1H-benzo[f]pyrrolo[3,2,1-ij]quinoline - was synthesized in nine steps. The synthetic approach uses both enantiomers of the chiral auxiliary trans-2,5-bis(methoxymethoxymethyl)pyrrolidine, employed in different stages of the synthesis for the construction of two out of the three stereogenic centers in the above mentioned intermediate.