3746-67-6

Usage

Uses

Used in Pharmaceutical Industry:
N-Acetyl-4-methoxymetanilyl chloride is utilized as a reagent in the synthesis of pharmaceuticals, contributing to the development of new drugs. Its unique chemical structure allows for the creation of a wide range of therapeutic agents, enhancing the industry's capacity to address various health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, N-Acetyl-4-methoxymetanilyl chloride serves as a reagent in the production of agrochemicals. Its application aids in the development of innovative products designed to improve crop protection and yield, thereby supporting sustainable agriculture practices.
Used in Chemical Research and Development:
N-Acetyl-4-methoxymetanilyl chloride is employed as a valuable intermediate in the preparation of high-value compounds. Its potential as a building block in the development of new drugs and materials makes it an essential component in advancing chemical research and development initiatives.

InChI:InChI=1/C9H10ClNO4S/c1-6(12)11-8-5-7(16(10,13)14)3-4-9(8)15-2/h3-5H,1-2H3,(H,11,12)

Upstream product

• 93-26-5 2-methoxyacetanilide 
• 7790-94-5 chlorosulfonic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 91170-71-7 3-acetylamino-4-methoxy-benzenesulfinic acid 
• 85605-29-4 3-acetylamino-4-methoxy-benzenesulfonic acid amide 
• 354575-09-0 3-acetylamino-4-methoxy-5-nitro-benzenesulfonyl chloride 
• 2488-63-3 N-(5-Hexadecylsulfamoyl-2-methoxy-phenyl)-acetamide 
• 87670-38-0 (S)-2-(3-Acetylamino-4-methoxy-benzenesulfonylamino)-propionic acid 
• 87670-39-1 (S)-2-(3-Acetylamino-4-methoxy-benzenesulfonylamino)-3-methyl-butyric acid 
• 87670-43-7 (S)-2-(3-Acetylamino-4-methoxy-benzenesulfonylamino)-3-phenyl-propionic acid 
• 87670-42-6 (S)-2-(3-Acetylamino-4-methoxy-benzenesulfonylamino)-3-(4-hydroxy-phenyl)-propionic acid 
• 860677-90-3 bis-(3-amino-4-methoxy-phenyl)-disulfide 
• 860578-28-5 bis-(3-acetylamino-4-methoxy-phenyl)-disulfide 
• 1146972-32-8 N'-[2-methoxy-5-(3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine 
• 1146972-31-7 N'-[5-(indole-1-sulfonyl)-2-methoxyphenyl]-N,N-dimethylethane-1,2-diamine 
• 1146972-30-6 N'-[5-(3-chloroindole-1-sulfonyl)-2-methoxyphenyl]-N,N-dimethylethane-1,2-diamine 
• 1146972-28-2 N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine 

Relevant academic research and scientific papers

Design, synthesis and pharmacological evaluation of indolylsulfonamide amines as potent and selective 5-HT6 receptor antagonists

A series of N′-[3-(indole-1-sulfonyl) aryl]-N,N-dimethyl ethane-1,2-diamines and N′-[3-(indole-1-sulfonyl) aryl]-N,N-dimethyl propane-1,3-diamines was designed and synthesized as 5-HT6 receptor ligands. These compounds, when screened in a functional reporter gene-based assay, displayed potent antagonistic activity with Kb values in the range of 1.8-60 nM. The lead compound 9y has shown good ADME surrogate properties, acceptable pharmacokinetic profile and is active in animal models of cognition like novel object recognition test and Morris water maze. It was selected for detailed profiling.

Aminoaryl sulphonamide derivatives as functional 5-HT6 ligands

The present invention provides aminoaryl sulphonamide derivatives of formula (I), useful in the treatment of a CNS disorder related to or affected by the 5-HT6 receptor. Pharmacological profiles of these components include high affinity binding with 5-HT6 receptors along with good selectivity towards the receptor. The present invention also includes stereoisomers, the salts, methods of preparation and medicine containing the aminoaryl sulphonamide derivatives.

AMINOARYL SULPHONAMIDE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS.

The present invention provides aminoaryl sulphonamide derivatives of formula (I), useful in the treatment of a CNS disorder related to or affected by the 5-HTg receptor. Pharmacological profile of these compounds includes high affinity binding with 5-HTg receptor along with good selectivity towards the said receptor. The present invention also includes the stereoisomers, the salts, methods of preparation and medicine containing the said aminoaryl sulphonamide derivatives.

PREVENTIVES/REMEDIES FOR POSTOPERATIVE STRESS

The present invention provides pharmaceutical composition for prophylaxis or/and therapy of a postoperative stress, which comprises a CRF antagonist.